| Author | Rodrigues, Rosana S. | |
| Author | Bozza, Fernando A. | |
| Author | Christian, Paul E. | |
| Author | Hoffman, John M. | |
| Author | Christensen, Carl R. | |
| Author | Butterfield, Regan I. | |
| Author | Wiggins, Richard H. | |
| Author | Heilbrun, Marta | |
| Author | Hunt, Jason P. | |
| Author | Bentz, Brandon G. | |
| Author | Hitchock, Ying J. | |
| Author | Morton, Kathryn A. | |
| Access date | 2019-12-30T15:21:33Z | |
| Available date | 2019-12-30T15:21:33Z | |
| Document date | 2009 | |
| Citation | RODRIGUES, Rosana S. et al. Comparison of whole-body PET/CT, dedicated high-resolution head and neck PET/CT, and contrast-enhanced CT in preoperative staging of clinically M0 squamous cell carcinoma of the head and neck. Journal of Nuclear Medicine, v. 50, n. 8, p. 1205-1213, Aug. 2009. | pt_BR |
| ISSN | 0161-5505 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/38909 | |
| Description | Fernando A. Bozza. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Society of Nuclear Medicine | pt_BR |
| Rights | open access | pt_BR |
| Title | Comparison of whole-body PET/CT, dedicated high-resolution head and neck PET/CT, and contrast-enhanced CT in preoperative staging of clinically M0 squamous cell carcinoma of the head and neck. | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.2967/jnumed.109.062075 | |
| Abstract | The purpose of this study was to compare optimized whole-body (WB) and dedicated high-resolution contrast-enhanced PET/CT protocols and contrast enhanced CT in the preoperative staging of primary squamous cell carcinoma of the head and neck. Methods: A total of 44 patients with clinically M0 squamous cell carcinoma of the head and neck underwent primary tumor resection and neck dissection within 6 wk of diagnostic imaging.
Imaging consisted of a standard WB PET/CT protocol without intravenous contrast enhancement, followed by a high-resolution dedicated head and neck (HN) PET/CT protocol, which included diagnostic-quality contrast-enhanced CT (CECT). Imaging results were compared with histopathology. A 5-point scale was used to designate primary tumor localization and the presence of lymph node metastasis on a per-patient and per-level basis. For cervical nodes, receiver-operating-characteristic curves were generated to determine the differences in performance between the WB and HN PET/CT protocols and CECT. Sensitivity, specificity, positive and negative predictive values, and accuracy were calculated for primary tumor and cervical nodes. Results: No statistical difference was observed between WB and HN PET/CT protocols, both of which significantly outperformed CECT, in the evaluation of the primary tumor. The performance of the HN PET/CT protocol was superior to that of the WB PET/CT in the detection of cervical node metastases, achieving statistical significance on a per-level basis and approaching significance on a per-patient basis, with the greatest advantage in the detection of small positive lymph nodes (,15 mm). No significant difference was observed between the WB PET/CT protocol and CECT in nodal staging, either on a per-patient or on a per-level basis. Conclusion: The primary advantage of the dedicated HN PET/CT protocol over the WB protocol or CECT in the staging of head and neck cancer is in the detection of small lymph node metastases. | pt_BR |
| Affilliation | National Institute of Science and Technology in Structural Biology and Bioimaging. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Department of Radiology. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | National Institute of Science and Technology in Structural Biology and Bioimaging. Rio de Janeiro, Brazil / Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University of Utah. Huntsman Cancer Institute. Salt Lake City, UT, USA. | pt_BR |
| Affilliation | University of Utah. Department of Radiology. Salt Lake City, UT, USA. | pt_BR |
| Affilliation | University of Utah. Huntsman Cancer Institute. Salt Lake City, UT, USA. | pt_BR |
| Affilliation | University of Utah. Department of Radiology. Salt Lake City, UT, USA. | pt_BR |
| Affilliation | University of Utah. Department of Radiology. Salt Lake City, UT, USA. | pt_BR |
| Affilliation | University of Utah. Department of Radiology. Salt Lake City, UT, USA. | pt_BR |
| Affilliation | University of Utah. Department of Surgery Division of Otolaryngology–Head and Neck Surgery. Salt Lake City, UT, USA. | pt_BR |
| Affilliation | University of Utah. Department of Surgery Division of Otolaryngology–Head and Neck Surgery. Salt Lake City, UT, USA. | pt_BR |
| Affilliation | University of Utah. Department of Radiation Oncology. Salt Lake City, UT, USA. | pt_BR |
| Affilliation | University of Utah. Department of Radiology. Salt Lake City, UT, USA. | pt_BR |
| Subject | Positron emission tomography | pt_BR |
| Subject | Computed tomography | pt_BR |
| Subject | Head and neck cancer | pt_BR |
| Subject | Squamous cell carcinoma | pt_BR |
| Subject | Tumor staging | pt_BR |
| e-ISSN | 2159-662X | |
| Embargo date | 2020-06-30 | |
| xmlui.metadata.dc.subject.ods | 13 Ação contra a mudança global do clima | |
