| Author | Santana, Eliane Corrêa de | |
| Author | Paez-Pereda, Marcelo | |
| Author | Theodoropoulou, Marily | |
| Author | Kenji Nihei, Oscar | |
| Author | Gruebler, Yvonne | |
| Author | Bozza, Marcelo | |
| Author | Arzt, Eduardo | |
| Author | Villa-Verde, Déa Maria Serra | |
| Author | Renner, Ulrich | |
| Author | Stalla, Johanna | |
| Author | Stalla, Günter Karl | |
| Author | Savino, Wilson | |
| Access date | 2020-01-03T14:17:41Z | |
| Available date | 2020-01-03T14:17:41Z | |
| Document date | 2006 | |
| Citation | SANTANA, Eliane Corrêa de et al. Hypothalamus-pituitary-adrenal axis during Trypanosoma cruz acute infection in mice. Journal of Neuroimmunology, v. 173, p. 12-22, 2006. | pt_BR |
| ISSN | 0165-5728 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/38964 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Citocinas | pt_BR |
| Subject in Portuguese | Fatores de transcrição | pt_BR |
| Subject in Portuguese | Interações neuroimunoendócrinas | pt_BR |
| Subject in Portuguese | Ratos | pt_BR |
| Title | Hypothalamus-pituitary-adrenal axis during Trypanosoma cruzi acute infection in mice | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.jneuroim.2005.08.015 | |
| Abstract | Functional interactions between neuroendocrine and immune systems are mediated by similar ligands and receptors, which establish a bi-directional communication that is relevant for homeostasis. We investigated herein the hypothalamus-pituitary-adrenal (HPA) axis in mice acutely infected by Trypanosoma cruzi, the causative agent of Chagas' disease. Parasites were seen in the adrenal gland, whereas T. cruzi specific PCR gene amplification product was found in both adrenal and pituitary glands of infected mice. Histological and immunohistochemical analyses of pituitary and adrenal glands of infected animals revealed several alterations including vascular stasis, upregulation of the extracellular matrix proteins fibronectin and laminin, as well as T cell and macrophage infiltration. Functionally, we detected a decrease in CRH and an increase in corticosterone contents, in hypothalamus and serum respectively. In contrast, we did not find significant changes in the amounts of ACTH in sera of infected animals, whereas the serum levels of the glucocorticoid-stimulating cytokine, IL-6 (interleukin-6), were increased as compared to controls. When we analyzed the effects of T. cruzi in ACTH-producing AtT-20 cell line, infected cultures presented lower levels of ACTH and pro-opiomelanocortin production when compared to controls. In these cells we observed a strong phosphorylation of STAT-3, together with an increased synthesis of IL-6, suppressor of cytokine signaling 3 (SOCS-3) and inhibitor of activated STAT-3 (PIAS-3), which could explain the partial blockage of ACTH production. In conclusion, our data reveal that the HPA axis is altered during acute T. cruzi infection, suggesting direct and indirect influences of the parasite in the endocrine homeostasis. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Max-Planck Institute of Psychiatry. Department of Endochrinology. Munich, Germany. | pt_BR |
| Affilliation | Max-Planck Institute of Psychiatry. Department of Endochrinology. Munich, Germany. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Max-Planck Institute of Psychiatry. Department of Endochrinology. Munich, Germany. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Prof. Paulo de Góes. Laboratório de Imunidade e Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade de Buenos Aires. Laboratório de Fisiologia e Biologia Molecular. Buenos Aires, Argentina. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Max-Planck Institute of Psychiatry. Department of Endochrinology. Munich, Germany. | pt_BR |
| Affilliation | Max-Planck Institute of Psychiatry. Department of Endochrinology. Munich, Germany. | pt_BR |
| Affilliation | Max-Planck Institute of Psychiatry. Department of Endochrinology. Munich, Germany. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | HPA axis | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | ACTH | pt_BR |
| Subject | Cytokines | pt_BR |
| Subject | Transcription factors | pt_BR |
| Subject | Neuroimmunoendocrine interactions | pt_BR |
| Subject | Mice | pt_BR |
| e-ISSN | 1872-8421 | |
| Embargo date | 2025-01-01 | |
