| Author | Ferreira, Marcelle de L. | |
| Author | Vasconcelos, Thatyana R. A. | |
| Author | Carvalho, Erika M. de | |
| Author | Lourenço, Maria C. S. | |
| Author | Wardell, Solange M. S. V. | |
| Author | Wardell, James L. | |
| Author | Ferreira, Vitor F. | |
| Author | Souza, Marcus V. N. de | |
| Access date | 2020-01-06T14:42:20Z | |
| Available date | 2020-01-06T14:42:20Z | |
| Document date | 2009 | |
| Citation | FERREIRA, Marcelle de L. et al. Synthesis and antitubercular activity of novel Schiff bases derived from d-mannitol. Carbohydrate Research, v. 344, p. 2042–2047, 2009. | pt_BR |
| ISSN | 0008-6215 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/38995 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | pt_BR |
| Title | Synthesis and antitubercular activity of novel Schiff bases derived from d-mannitol | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.carres.2009.08.006 | |
| Abstract | Six Schiff base derivatives of D-mannitol, 1,6-dideoxy-1,6-bis-{[(E)-arylmethylidene]amino}-D-mannitol (6: aryl = XC6H4: X=o-,m- and p-ClorNO2), have been synthesized and evaluated for their in vitro anti-bacterial activity against Mycobacterium tuberculosis H37Rv using the Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC) in μg/mL. All three nitro derivatives exhibit significant activities: activities of (6d: X=o-NO2), (6e: X=m-NO2) and (6f: X=p-NO2) are 12.5, 25.0 and 25.0 μg/mL, respectively. When compared with first line drugs, such as ethambutol, they can be considered as a good starting point to develop new lead compounds for the treatment of multi-drug-resistant tuberculosis. Characterization of the new compounds 6 is generally achieved spectroscopically. The structure of compound 3 has been confirmed by X-ray crystallography. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Instituto de Química. Departamento de Química Orgânica. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Química. Departamento de Química Orgânica. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisas Clínicas Evandro Chagas. Departamento de Bacteriologia. Rio de Janeiro, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University of Aberdeen. Department of Chemistry. Old Aberdeen, Scotland, UK / Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Química. Departamento de Química Orgânica. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | D-mannitol | pt_BR |
| Subject | Schiff bases | pt_BR |
| Subject | Antitubercular activity | pt_BR |
| e-ISSN | 1873-426X | |
| Embargo date | 2021-01-06 | |
