| Author | Dantas, Andreia P. | |
| Author | Olivieri, Bianca P. | |
| Author | Gomes, Fátima H. M. | |
| Author | Castro, Solange L. de | |
| Access date | 2020-01-16T10:56:48Z | |
| Available date | 2020-01-16T10:56:48Z | |
| Document date | 2006 | |
| Citation | DANTAS, Andreia P. et al. Treatment of Trypanosoma cruzi-infected mice with propolis promotes changes in the immune response. Journal of Ethnopharmacology, v. 103, p. 187-193, 2006. | pt_BR |
| ISSN | 0378-8741 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/39245 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Subject in Portuguese | Quimioterapia | pt_BR |
| Title | Treatment of Trypanosoma cruzi-infected mice with propolis promotes changes in the immune response | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.jep.2005.07.018 | |
| Abstract | Ethanol extract of Bulgarian propolis (Et-Blg) was administered by oral route in doses ranging from 25 to 100mg/kg body weight in experimental Trypanosoma cruzi-infected Swiss mice. Treatment with 50mg Et-Blg/kg body weight/day led to a decrease in parasitemia and showed no hepatic or renal toxic effect. Treatment with Et-Blg led to a decrease in the spleen mass and modulated the initial inflammatory reaction as demonstrated by analysis of the leukocyte profile in peripheral blood, quantification of T cells subsets, and phenotypic markers in the spleen. Preferential expansion of CD8(+) and partial inhibition in the increase of CD4(+)CD69(+) and CD8(+)CD69(+) in CD4(+)CD44(+) and CD8(+)CD44(+) and in the decrease of CD8(+)CD62L in Trypanosoma cruzi-infected mice were also observed. Taken together, our data indicate that treatment of Trypanosoma cruzi-infected mice with Et-Blg interferes with the basic properties of immune cells. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | Chagas Disease | pt_BR |
| Subject | Chemotherapy | pt_BR |
| e-ISSN | 1872-7573 | |
| Embargo date | 2022-01-01 | |
