| Author | Waghabi, Mariana C. | |
| Author | Keramidas, Michelle | |
| Author | Calvet, Claudia M. | |
| Author | Meuser, Marcos | |
| Author | Soeiro, Maria de Nazaré C. | |
| Author | Lima, Leila Mendonça | |
| Author | Araujo-Jorge, Tania C. | |
| Author | Feige, Jean-Jacques | |
| Author | Bailly, Sabine | |
| Access date | 2020-01-20T18:33:34Z | |
| Available date | 2020-01-20T18:33:34Z | |
| Document date | 2007 | |
| Citation | WAGHABI, Mariana C. et al. SB-431542, a transforming growth factor β inhibitor, impairs Trypanosoma cruzi infection in cardiomyocytes and parasite cycle completion. Antimicrobial Agents and Chemotherapy, v. 51, n. 8. p. 2905-2910, Aug. 2007. | pt_BR |
| ISSN | 0066-4804 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/39326 | |
| Language | eng | pt_BR |
| Publisher | American Society for Microbiology | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | SB-431542 | pt_BR |
| Subject in Portuguese | Inibidor do fator de crescimento | pt_BR |
| Subject in Portuguese | Cardiomiócitos | pt_BR |
| Subject in Portuguese | Ciclo parasitário | pt_BR |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Infecção | pt_BR |
| Title | SB-431542, a transforming growth factor β inhibitor, impairs Trypanosoma cruzi infection in cardiomyocytes and parasite cycle completion | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1128/AAC.00022-07 | |
| Abstract | The antiinflammatory cytokine transforming growth factor beta (TGF-beta) plays an important role in Chagas disease, a parasitic infection caused by the protozoan Trypanosoma cruzi. In the present study, we show that SB-431542, an inhibitor of the TGF-beta type I receptor (ALK5), inhibits T. cruzi-induced activation of the TGF-beta pathway in epithelial cells and in cardiomyocytes. Further, we demonstrate that addition of SB-431542 greatly reduces cardiomyocyte invasion by T. cruzi. Finally, SB-431542 treatment significantly reduces the number of parasites per infected cell and trypomastigote differentiation and release. Taken together, these data further confirm the major role of the TGF-beta signaling pathway in both T. cruzi infection and T. cruzi cell cycle completion. Our present data demonstrate that small inhibitors of the TGF-beta signaling pathway might be potential pharmacological tools for the treatment of Chagas disease. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Institut National de la Santé et de la Recherche Médicale. Grenoble, France / Institut de Recherches en Technologies et Sciences pour le Vivant. France / Angiogenèse et Physiopathologie Vasculaire. Grenoble, France / Université Joseph Fourier, Grenoble, France. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Institut National de la Santé et de la Recherche Médicale. Grenoble, France / Institut de Recherches en Technologies et Sciences pour le Vivant. France / Angiogenèse et Physiopathologie Vasculaire. Grenoble, France / Université Joseph Fourier, Grenoble, France. | pt_BR |
| Affilliation | Institut National de la Santé et de la Recherche Médicale. Grenoble, France / Institut de Recherches en Technologies et Sciences pour le Vivant. France / Angiogenèse et Physiopathologie Vasculaire. Grenoble, France / Université Joseph Fourier, Grenoble, France. | pt_BR |
| Subject | SB-431542 | pt_BR |
| Subject | Transforming growth factor inhibitor | pt_BR |
| Subject | Cardiomyocytes | pt_BR |
| Subject | Parasite Cycle | pt_BR |
| Subject | Trypanosoma cruzi Infection | pt_BR |
| e-ISSN | 1098-6596 | |
| Embargo date | 2025-01-01 | |
