| Author | Gentile, Carla | |
| Author | Meireles Filho, Antonio C. A. | |
| Author | Britto, Constança | |
| Author | Lima, José B. P. | |
| Author | Valle, Denise | |
| Author | Peixoto, Alexandre A. | |
| Access date | 2020-01-21T11:21:52Z | |
| Available date | 2020-01-21T11:21:52Z | |
| Document date | 2006 | |
| Citation | GENTILE, Carla et al. Cloning and daily expression of the timeless gene in Aedes aegypti (Diptera:Culicidae). Insect Biochemistry and Molecular Biology, v. 36, p. 878-884, 2006. | pt_BR |
| ISSN | 0965-1748 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/39331 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Aedes aegypti | pt_BR |
| Subject in Portuguese | Dengue | pt_BR |
| Subject in Portuguese | Mosquitos | pt_BR |
| Subject in Portuguese | Febre amarela | pt_BR |
| Subject in Portuguese | Relógio biológico | pt_BR |
| Subject in Portuguese | Ritmo Circadiano | pt_BR |
| Title | Cloning and daily expression of the timeless gene in Aedes aegypti (Diptera:Culicidae) | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.ibmb.2006.08.008 | |
| Abstract | Molecular approaches for studying biological rhythms in insects have been well investigated in the model Drosophila melanogaster, in which a number of genes have been characterized in terms of sequence, expression, protein interactions and involvement in the control of locomotor activity and eclosion rhythms. However, only scattered information is available for insect vectors of diseases. In this paper, we report the cloning and expression analysis of the clock gene timeless in the mosquito Aedes aegypti, vector of Dengue and Yellow Fever viruses. In Drosophila, timeless has a crucial role in the control of the central pacemaker and the resetting mechanism that allows the clock to synchronize with the environment light-dark cycles. Comparison of the predicted protein sequence encoded by timeless in Ae. aegypti and D. melanogaster demonstrated high similarity in some important domains, suggesting functional conservation. Analysis of the daily expression of timeless in Ae. aegypti shows a peak in mRNA abundance around the light-dark transition. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Entomologia. Rio de Janeiro, RJ, Brasil / Instituto de Biologia do Exército. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Entomologia. Rio de Janeiro, RJ, Brasil / Instituto de Biologia do Exército. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Timeless | pt_BR |
| Subject | Biological clock | pt_BR |
| Subject | Circadian rhythms | pt_BR |
| Subject | Aedes aegypti | pt_BR |
| Subject | Mosquitoes | pt_BR |
| Subject | Dengue | pt_BR |
| Subject | Yellow fever | pt_BR |
| e-ISSN | 1879-0240 | |
| Embargo date | 2022-01-01 | |
