| Author | Meirelles Filho, Antonio C. A. | |
| Author | Amoretty, Paulo R. | |
| Author | Souza, Nataly A. | |
| Author | Kyriacou, Charalambos P. | |
| Author | Peixoto, Alexandre A. | |
| Access date | 2020-01-23T10:29:10Z | |
| Available date | 2020-01-23T10:29:10Z | |
| Document date | 2006 | |
| Citation | MEIRELES FILHO, Antonio C. A. et al. Rhythmic expression of the cycle gene in a hematophagous insect vector. BMC Molecular Biology, v. 7, n. 38, p. 1-10, Oct. 2006. | pt_BR |
| ISSN | 1471-2199 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/39442 | |
| Language | eng | pt_BR |
| Publisher | BioMed Central | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Drosophila melanogaster | pt_BR |
| Subject in Portuguese | Espécies de vetores hematófagos | pt_BR |
| Subject in Portuguese | Expressão rítimica | pt_BR |
| Subject in Portuguese | Gene do ciclo | pt_BR |
| Title | Rhythmic expression of the cycle gene in a hematophagous insect vector | pt_BR |
| Type | Article | |
| DOI | 10.1186/1471-2199-7-38 | |
| Abstract | A large number of organisms have internal circadian clocks that enable them to
adapt to the cyclic changes of the external environment. In the model organism Drosophila
melanogaster, feedback loops of transcription and translation are believed to be crucial for the
maintenance of the central pacemaker. In this mechanism the cycle (or bmal1) gene, which is
constitutively expressed, plays a critical role activating the expression of genes that will later inhibit
their own activity, thereby closing the loop. Unlike Drosophila, the molecular clock of insect vectors
is poorly understood, despite the importance of circadian behavior in the dynamic of disease
transmission. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Entomologia. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | University of Leicester. Department of Genetics. Leicester, United Kingdom. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Drosophila melanogaster | pt_BR |
| Subject | Hematophagous vector species | pt_BR |
| Subject | Rhythmic expression | pt_BR |
| Subject | Cycle gene | pt_BR |
