| Author | Maia, Renata Monteiro | |
| Author | Sampaio, Maria B. Ortigão de | |
| Author | Pinho, Rosa T. | |
| Author | Castello Branco, Luiz R. R. | |
| Access date | 2020-01-23T13:03:09Z | |
| Available date | 2020-01-23T13:03:09Z | |
| Document date | 2006 | |
| Citation | MAIA, Renata Monteiro et al. Modulation of humoral immune response to oral BCG vaccination by Mycobacterium bovis BCG Moreau Rio de Janeiro (RDJ) in healthy adults. Journal of Immune Based Therapies and Vaccines. v. 4, n. 4, p. 1-6, 2006. | pt_BR |
| ISSN | 1476-8518 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/39455 | |
| Language | eng | pt_BR |
| Publisher | BioMed Central | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Resposta imune humoral | pt_BR |
| Subject in Portuguese | Vacinação oral ao BCG | pt_BR |
| Subject in Portuguese | Mycobacterium bovis BCG Moreau | pt_BR |
| Subject in Portuguese | Adultos saudáveis | pt_BR |
| Subject in Portuguese | Rio de Janeiro | pt_BR |
| Title | Modulation of humoral immune response to oral BCG vaccination by Mycobacterium bovis BCG Moreau Rio de Janeiro (RDJ) in healthy adults | pt_BR |
| Type | Article | |
| DOI | 10.1186/1476-8518-4-4 | |
| Abstract | Background: Oral administration of BCG was the route initially used by Calmette and Guérin, but was replaced by intradermal administration in virtually all countries after the Lubeck accident. However, Brazil continued to administer oral BCG Moreau RDJ, which was maintained until the mid-1970s when it was substituted by the intradermal route. Although BCG vaccination has been used in humans since 1921, little is known of the induced immune response. The aim of this study was to analyse immunological responses after oral vaccination with M. bovis BCG Moreau RDJ. Methods: This study in healthy volunteers has measured cellular and humoral aspects of the immunological response to oral M. bovis BCG Moreau RDJ in Rio de Janeiro, Brazil. T-cell trafficking and Th1 and Th2 cytokine responses are described, as well as isotype-specific antibody production using novel techniques. Results: Oral immunisation has no adverse effects. We have shown that there are cellular and humoral immunological responses after oral immunisation. Oral revaccination does not induce a positive skin test in responsive individuals and multiple booster orally was able to induce modulation in humoral immunological responses (switch from IgG to IgA) in previously immunised subjects and incapable of inducing tolerance. In contrast, the cellular immune response does not differ between vaccinated individuals with positive and negative skin test reactions. Conclusion: All subjects, including those who did not respond to the skin test at study commencement, were capable of mounting humoral and cellular immune response to the antigens tested. | pt_BR |
| Affilliation | Fundação Ataulpho de Paiva. Centro de Pesquisas Arlindo de Assis. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | St. George's, Cranmer Terrace. Cellular & Molecular Medicine (Centre for Infection). London, United Kingdom. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Ataulpho de Paiva. Centro de Pesquisas Arlindo de Assis. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Humoral immune response | pt_BR |
| Subject | Oral BCG vaccination | pt_BR |
| Subject | Mycobacterium bovis BCG Moreau | pt_BR |
| Subject | Rio de Janeiro | pt_BR |
| Subject | Healthy adults | pt_BR |
| e-ISSN | 1476-8518 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
