| Author | Andrade, Cynthia de Paula | |
| Author | Coelho, Paulo Ricardo Silva | |
| Author | Nascimento, Ricardo Aurélio Pinto | |
| Author | Mota, Pedro Moacyr Pinto Coelho | |
| Author | Silva, Marco Aurélio Romano | |
| Author | Alvarenga, Kevin Augusto Faria de | |
| Author | Schall, Virgínia Torres | |
| Author | Pimenta, Denise Nacif | |
| Author | Coelho, Paulo Marcos Zech | |
| Author | Oliveira, Edward José de | |
| Access date | 2020-01-31T16:04:40Z | |
| Available date | 2020-01-31T16:04:40Z | |
| Document date | 2019 | |
| Citation | ANDRADE, Cynthia de Paula et al. Development of a natural molluscicide prototype kit (MoluSchall) for the control of schistosomiasis mansoni transmission. Revista da Sociedade Brasileira de Medicina Tropical, v. 52, p. 1-8, 2019. | pt_BR |
| ISSN | 0037-8682 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/39662 | |
| Language | eng | pt_BR |
| Publisher | Sociedade Brasileira de Medicina Tropical | pt_BR |
| Rights | open access | pt_BR |
| Title | Development of a natural molluscicide prototype kit (MoluSchall) for the control of schistosomiasis mansoni transmission | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1590/0037-8682-0252-2019 | pt_BR |
| Abstract | INTRODUCTION: In Brazil, Biomphalaria glabrata, B. tenagophila, and B. straminea are intermediate hosts of Schistosoma mansoni, the etiological agent of schistosomiasis mansoni. Molluscicide use is recommended by the WHO for controlling the transmission of this parasite. Euphorbia milii latex has shown promising results as an alternative molluscicide. Thus, a natural molluscicide prototype kit based on freeze-dried E. milii latex was developed and evaluated against Biomphalaria spp.
METHODS: E. milii latex was collected, processed, and lyophilized. Two diluents were defined for freeze-dried latex rehydration, and a prototype kit, called MoluSchall, was produced. A stability test was conducted using prototype kits stored at different temperatures, and a toxicity assay was performed using Danio rerio. Additionally, MoluSchall was tested against B. glabrata under semi-natural conditions according to defined conditions in the laboratory.
RESULTS: MoluSchall was lethal to three Brazilian snail species while exhibiting low toxicity to D. rerio. Regardless of storage temperature, MoluSchall was stable for 24 months and was effective against B. glabrata under semi-natural conditions, with the same LD100 as observed under laboratory conditions.
CONCLUSIONS: MoluSchall is a natural, effective, and inexpensive molluscicide with lower environmental toxicity than existing molluscicides. Its production offers a possible alternative strategy for controlling S. mansoni transmission. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Oncológicas. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Oncológicas. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Laboratório Nacional Agropecuário. Pedro Leopoldo, MG, Brasil. | pt_BR |
| Affilliation | Laboratório Nacional Agropecuário. Pedro Leopoldo, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Laboratório de Neurociência. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Laboratório de Neurociência. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Pesquisa Clínica e Políticas Públicas em Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Pesquisa Clínica e Políticas Públicas em Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Oncológicas. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Pesquisa Clínica e Políticas Públicas em Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brasil. | pt_BR |
| Subject | Euphorbia milii | pt_BR |
| Subject | MoluSchall | pt_BR |
| Subject | Natural molluscicide | pt_BR |
| Subject | Prototype kit | pt_BR |
| Subject | Schistosomiasis control | pt_BR |
| e-ISSN | 10.1590/0037-8682-0252-2019 | |
