| Author | Spencer, Lisa A. | |
| Author | Melo, Rossana C. N. | |
| Author | Perez, Sandra A. C. | |
| Author | Bafford, Staci P. | |
| Author | Dvorak, Ann M. | |
| Author | Weller, Peter F. | |
| Access date | 2020-02-04T14:56:42Z | |
| Available date | 2020-02-04T14:56:42Z | |
| Document date | 2006 | |
| Citation | SPENCER, Lisa A. et al. Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion. Proceedings of the National Academy of Sciences (PNAS), v. 103, n. 9, p. 3333-3338, Feb. 2006. | pt_BR |
| ISSN | 0027-8424 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/39713 | |
| Language | eng | pt_BR |
| Publisher | National Academy of Sciences | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Receptor intracelular de citocinas | pt_BR |
| Subject in Portuguese | Transporte vesicular | pt_BR |
| Subject in Portuguese | Tráfico intracelular de citocinas | pt_BR |
| Subject in Portuguese | Degranulação fragmentada | pt_BR |
| Title | Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion | pt_BR |
| Type | Article | |
| DOI | 10.1073/pnas.0508946103 | |
| Abstract | Although leukocytes of the innate immune system, including eosinophils, contain within their granules preformed stores of cytokines available for selective and rapid release, little is known about the mechanisms governing the mobilization and secretion of these cytokines. Here we show that a cytokine receptor, the IL-4 receptor alpha chain, mediates eotaxin-stimulated mobilization of preformed IL-4 from eosinophil granules into secretory vesicles. Eosinophils contain substantial intracellular quantities of several granule- and vesicle-associated cytokine receptors, including IL-4, IL-6, and IL-13 receptors as well as CCR3. Both IL-4 and IL-4 receptor alpha chain colocalized in eosinophil granules; and after eotaxin-stimulation, IL-4 receptor alpha chain, bearing bound IL-4, was mobilized into secretory vesicles. These findings indicate that intracellular cytokine receptors within secretory vesicles transport their cognate cytokines requisite for the secretion of cytokines preformed in innate immune leukocytes. | pt_BR |
| Affilliation | Harvard Medical School. Beth Israel Deaconess Medical Center. Department of Medicine. Boston, MA, USA. | pt_BR |
| Affilliation | Harvard Medical School. Beth Israel Deaconess Medical Center. Department of Medicine. Boston, MA, USA / Universidade Federal de Juiz de Fora. Departamento de Biologia. Juiz de Fora, MG, Brasil. | pt_BR |
| Affilliation | Harvard Medical School. Beth Israel Deaconess Medical Center. Department of Medicine. Boston, MA, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Harvard Medical School. Beth Israel Deaconess Medical Center. Department of Medicine. Boston, MA, USA. | pt_BR |
| Affilliation | Harvard Medical School. Beth Israel Deaconess Medical Center. Department of Pathology. Boston, MA, USA. | pt_BR |
| Affilliation | Harvard Medical School. Beth Israel Deaconess Medical Center. Department of Medicine. Boston, MA, USA. | pt_BR |
| Subject | Intracellular cytokine receptor | pt_BR |
| Subject | Intracellular cytokine trafficking | pt_BR |
| Subject | Piecemeal degranulation | pt_BR |
| Subject | Vesicular transport | pt_BR |
| e-ISSN | 1091-6490 | |
| xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero | |
| xmlui.metadata.dc.subject.ods | 11 Cidades e comunidades sustentáveis | |
| xmlui.metadata.dc.subject.ods | 16 Paz, Justiça e Instituições Eficazes | |
