| Author | Castro, Renata Rodrigues Teixeira de | |
| Author | Tibiriçá, Eduardo | |
| Author | Oliveira, Marcos Aurélio Brazão de | |
| Author | Moreira, Paula Barbosa Baptista | |
| Author | Catelli, Marcelo Flores | |
| Author | Rocha, Nazareth Novaes | |
| Author | Nóbrega, Antonio C. L. | |
| Access date | 2020-02-04T15:33:31Z | |
| Available date | 2020-02-04T15:33:31Z | |
| Document date | 2006 | |
| Citation | CASTRO, Renata Rodrigues Teixeira et al. Reduced Hemodynamic Responses to Physical and Mental Stress Under Low-Dose Rilmenidine in Healthy Subjects. Cardiovascular Drugs and Therapy, v. 20, p. 129-134, 2006. | pt_BR |
| ISSN | 0920-3206 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/39718 | |
| Language | eng | pt_BR |
| Publisher | Springer | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Rilmenidina | pt_BR |
| Subject in Portuguese | Teste de esforço | pt_BR |
| Subject in Portuguese | Estresse mental | pt_BR |
| Subject in Portuguese | Sistema nervoso simpático | pt_BR |
| Title | Reduced hemodynamic responses to physical and mental stress under low-dose rilmenidine in healthy subjects | pt_BR |
| Type | Article | |
| DOI | 10.1007/s10557-006-7653-8 | |
| Abstract | Activation of the sympathetic nervous system plays a major role in the pathogenesis and prognosis of cardiovascular diseases. Rilmenidine is an I(1)-imidazoline receptor agonist that reduces blood pressure by modulation of central sympathetic activity, but the effects of low-dose rilmenidine on the hemodynamic responses to physiological maneuvers that increase adrenergic drive is not known. To assess the effects of low-dose rilmenidine on the hemodynamic responses to stress, 32 healthy subjects (20-56 years old) underwent acute physical exercise (n = 15, individualized ramp protocol on treadmill) and mental stress (n = 17, word color Stroop and mental arithmetics tests) two hours after the oral administration of 0.5 mg of rilmenidine (RIL) or placebo (PLA) following a randomized, double-blind, placebo controlled crossover study. No subject complained of any side effect. Rilmenidine reduced peak exercise heart rate (PLA: 187 +/- 7; RIL: 181 +/- 9 bpm; P = 0.003), but did not modify peak aerobic power (VO(2max) - PLA: 41.7 +/- 6.2; RIL: 42.3 +/- 6.7 ml/kg/min; P = 0.26). During mental stress, rilmenidine inhibited the peak systolic (PLA: 123 +/- 10; RIL: 114 +/- 8 mmHg; P = 0.02) and diastolic (PLA: 86 +/- 7; RIL: 81 +/- 7 mmHg; P <0.05) blood pressure responses. In conclusion, rilmenidine reduced the hemodynamic response to physical and mental stress stimuli without limiting exercise capacity. These results support the concept that rilmenidine, at a dose lower than the ones recommended to treat hypertension, reduced the myocardial oxygen demand to stress and may carry potential clinical impact. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto Biomédico. Departamento de Fisiologia e Farmacologia. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Pós-Graduação em Ciências Cardiovasculares. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Pós-Graduação em Ciências Cardiovasculares. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto Biomédico. Departamento de Fisiologia e Farmacologia. Niterói, RJ, Brasil. | pt_BR |
| Subject | Rilmenidine | pt_BR |
| Subject | Exercise test | pt_BR |
| Subject | Mental stress | pt_BR |
| Subject | Sympathetic activity | pt_BR |
| e-ISSN | 1573-7241 | |
| Embargo date | 2025-01-01 | |
