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AutorMichel, Marie-Laure
AutorCruz, Daniella Mendes da
AutorKeller, Alexandre Castro
AutorLochner, Matthias
AutorSchneider, Elke
AutorDy, Michel
AutorEbert, Gérard
AutorMoraes, Maria C. Leite de
Fecha de acceso2020-02-11T14:08:55Z
Fecha de disponibilización2020-02-11T14:08:55Z
Fecha de publicación2008
ReferenciaMICHEL, Marie-Laure et al. Critical role of ROR t in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation. Proceedings of the National Academy of Sciences of the United States of America (PNAS), v; 105. n. 50, p. 19845-19850, Dec. 2008.pt_BR
ISSN0027-8424pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/39842
Idiomaengpt_BR
EditorNational Academy of Sciencespt_BR
Derechos de autoropen access
Palabras clave en PortuguésCélulas T Matadoras Naturaispt_BR
Palabras clave en PortuguésCitocinaspt_BR
TítuloCritical role of ROR t in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiationpt_BR
Tipo del documentoArticle
DOI10.1111/j.1472-765X.2008.02322.x
Resumen en InglésInvariant natural killer T (iNKT) cells constitute a subpopulation of T cells that recognize glycolipids presented by CD1d molecules. They are characterized by their prompt production of interleukin-4 (IL-4) and interferon- (IFN- ), which enables them to modulate diverse immune responses. Recently, we enlarged this concept by identifying a distinct IL-17-producing iNKT cell subset, named iNKT17 cells. The mechanisms leading to the acquisition of this new iNKT cell activity are unknown. Herein we show that IL-17-producing iNKT cells are already present in the thymus, predominantly among a subset regarded so far as an immature stage of thymic iNKT cell development, the CD1d tetramerposCD44posNK1.1negCD4neg cells. Using EGFP reporter mice, we demonstrate that the transcription factor ROR- t is critical for the thymic differentiation of this subset because only ROR- tpos iNKT cells are capable of massively secreting IL-17. Moreover, IL-17-producing CD1d tetramerposCD44posNK1.1negCD4neg thymic iNKT cells have reached a mature differentiation stage because they fail to generate other cell subsets in fetal thymic organ culture. Conversely, thymic ROR- tneg iNKT cell precursors give rise to progeny, but acquire neither ROR- t expression nor the ability to secrete IL-17. In conclusion, our findings demonstrate an alternative thymic pathway leading to the development of iNKT17 cells that requires ROR- t expression.pt_BR
AfiliaciónUniversité Paris Descartes. Faculté de Médecine. Centre National de la Recherche Scientifique. Unité Mixte de Recherche 8147. Hôpital Necker. Paris, France.pt_BR
AfiliaciónUniversité Paris Descartes. Faculté de Médecine. Centre National de la Recherche Scientifique. Unité Mixte de Recherche 8147. Hôpital Necker. Paris, France / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónUniversité Paris Descartes. Faculté de Médecine. Centre National de la Recherche Scientifique. Unité Mixte de Recherche 8147. Hôpital Necker. Paris, France / University Federal de Sao Paulo. São Paulo, SP, Brasil.pt_BR
AfiliaciónInstitut Pasteur. Centre National de la Recherche Scientifique. Unité de Recherche Associée 1961. Laboratory of Lymphoid Tissue Development. Paris, France.pt_BR
AfiliaciónUniversité Paris Descartes. Faculté de Médecine. Centre National de la Recherche Scientifique. Unité Mixte de Recherche 8147. Hôpital Necker. Paris, France.pt_BR
AfiliaciónUniversité Paris Descartes. Faculté de Médecine. Centre National de la Recherche Scientifique. Unité Mixte de Recherche 8147. Hôpital Necker. Paris, France.pt_BR
AfiliaciónInstitut Pasteur. Centre National de la Recherche Scientifique. Unité de Recherche Associée 1961. Laboratory of Lymphoid Tissue Development. Paris, France.pt_BR
AfiliaciónUniversité Paris Descartes. Faculté de Médecine. Centre National de la Recherche Scientifique. Unité Mixte de Recherche 8147. Hôpital Necker. Paris, France.pt_BR
Palavras clave en InglêsThymic precursorspt_BR
Palavras clave en InglêsGalCerpt_BR
Palavras clave en InglêsCD1dpt_BR
Palavras clave en InglêsCytokinespt_BR
e-ISSN1091-6490


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