| Author | Costa, Erico Castro | |
| Author | Diniz, Breno Satler | |
| Author | Firmo, Josélia Oliveira Araújo | |
| Author | Peixoto, Sérgio William Viana | |
| Author | Loyola Filho, Antônio Ignácio de | |
| Author | Costa, Maria Fernanda Furtado Lima | |
| Author | Blay, Sergio Luiz | |
| Access date | 2020-02-11T16:30:51Z | |
| Available date | 2020-02-11T16:30:51Z | |
| Document date | 2019 | |
| Citation | COSTA, Erico Castro et al. Diabetes, depressive symptoms, and mortality risk in old age: The role of inflammation. Depression and Anxiety, v. 36, n. 10, p. 941-949, 2019. | pt_BR |
| ISSN | 1091-4269 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/39860 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Diabetes, depressive symptoms, and mortality risk in old age: The role of inflammation | pt_BR |
| Type | Article | |
| DOI | 10.1002/da.22908 | |
| Abstract | BACKGROUND: Both diabetes and depression increase the mortality risk in the elderly. In this study, we evaluated mortality risk associated with the comorbidity between depression and diabetes. We also assessed the moderating role of inflammation in the mortality risk in this population.
METHODS: We included a total of 1,183 community-dwelling older adults, divided into four groups: "neither diabetes nor depression"; "diabetes only"; "depression only," and "both diabetes and depression," and followed-up for a median of 13.5 years. We evaluated the inflammatory status by the high-sensitivity C-reactive protein (hs-CRP) levels. Date of death was computed by reviewing death certificates. We used Cox's proportional hazards models and additive interactions to evaluate the risk of mortality in the subject groups and the moderating effect of hs-CRP.
RESULTS: Participants with both diabetes and depression had higher death risk (hazard ratio [HR]: 2.33; 95% confidence interval [CI]: 1.59-3.42) than those with each condition alone (HR diabetes: 2.08 95% CI: 1.56-2.76 HR depression: 1.26; 95% CI: 1.03-1.54). High level of hs-CRP, indicative of high inflammatory status, significantly moderated the risk of mortality in subjects with both diabetes and depression (Bonferroni-adjusted p = 0.0116).
CONCLUSIONS: The coexistence of diabetes and depression symptoms is associated with the highest death risk in this population. This risk is moderated by inflammatory status. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Centro de Estudos em Saúde Pública e Envelhecimento. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Department of Psychiatry, Faculty of Medicine University Toronto, Geriatric Psychiatry Division, Center for Addiction and Mental Health. Toronto, Ontario, Canada. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Centro de Estudos em Saúde Pública e Envelhecimento. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Centro de Estudos em Saúde Pública e Envelhecimento. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Escola de Enfermagem. Departamento de Enfermagem Aplicada. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Centro de Estudos em Saúde Pública e Envelhecimento. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Escola de Enfermagem. Departamento de Enfermagem Aplicada. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Centro de Estudos em Saúde Pública e Envelhecimento. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Medicina Social e Preventiva. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de São Paulo. Faculdade de Medicina. Departamento de Psiquiatria. São Paulo, SP, Brasil. | pt_BR |
| Subject | Comorbidity | pt_BR |
| Subject | Depression | pt_BR |
| Subject | Diabetes | pt_BR |
| Subject | Elderly | pt_BR |
| Subject | Follow up | pt_BR |
| Subject | Inflammation | pt_BR |
| Subject | Mortality | pt_BR |
| Embargo date | 2025-01-01 | |
