| Author | Joyner, Chester J. | |
| Author | Brito, Cristiana Ferreira Alves de | |
| Author | Saney, Celia L. | |
| Author | Cordy, Regina Joice | |
| Author | Smith, Maren L. | |
| Author | Cabrera-Mora, Monica | |
| Author | Kyu, Shuya | |
| Author | Lackman, Nicolas | |
| Author | Nural, Mustafa V. | |
| Author | DeBarry, Jeremy D. | |
| Author | Kissinger, Jessica C. | |
| Author | Styczynski, Mark P. | |
| Author | Eun-Hyung Lee, F. | |
| Author | Lamb, Tracey J. | |
| Author | Galinski, Mary R. | |
| Access date | 2020-02-17T13:53:01Z | |
| Available date | 2020-02-17T13:53:01Z | |
| Document date | 2019 | |
| Citation | JOYNER, Chester J. et al. Humoral immunity prevents clinical malaria during Plasmodium relapses without eliminating gametocytes. PLoS Pathogens, v. 15, n. 9, p. 1-36, 2019. | pt_BR |
| ISSN | 1553-7366 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/40006 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Humoral immunity prevents clinical malaria during Plasmodium relapses without eliminating gametocytes | pt_BR |
| Type | Article | |
| DOI | 10.1371/journal.ppat.1007974 | |
| Abstract | Plasmodium relapses are attributed to the activation of dormant liver-stage parasites and are responsible for a significant number of recurring malaria blood-stage infections. While characteristic of human infections caused by P. vivax and P. ovale, their relative contribution to malaria disease burden and transmission remains poorly understood. This is largely because it is difficult to identify ‘bona fide’ relapse infections due to ongoing transmission in most endemic areas. Here, we use the P. cynomolgi–rhesus macaque model of relapsing malaria to demonstrate that clinical immunity can form after a single sporozoite-initiated blood-stage infection and prevent illness during relapses and homologous reinfections. By integrating data from whole blood RNA-sequencing, flow cytometry, P. cynomolgi-specific ELISAs, and opsonic phagocytosis assays, we demonstrate that this immunity is associated with a rapid recall response by memory B cells that expand and produce anti-parasite IgG1 that can mediate parasite clearance of relapsing parasites. The reduction in parasitemia during relapses was mirrored by a reduction in the total number of circulating gametocytes, but importantly, the cumulative proportion of gametocytes increased during relapses. Overall, this study reveals that P. cynomolgi relapse infections can be clinically silent in macaques due to rapid memory B cell responses that help to clear asexual-stage parasites but still carry gametocytes. | pt_BR |
| Affilliation | Malaria Host–Pathogen Interaction Center. Emory Vaccine Center. Yerkes National Primate Research Center. Emory University. Atlanta, GA, USA / Division of Pulmonary, Allergy, Critical Care, & Sleep Medicine. Department of Medicine. Emory University. Atlanta, GA, USA. | pt_BR |
| Affilliation | Malaria Host–Pathogen Interaction Center. Emory Vaccine Center. Yerkes National Primate Research Center. Emory University. Atlanta, GA, USA / Fundação Oswaldo Cruz. Instituto René Rachou. Laboratory of Malaria. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Malaria Host–Pathogen Interaction Center. Emory Vaccine Center. Yerkes National Primate Research Center. Emory University. Atlanta, GA, USA / Division of Pulmonary, Allergy, Critical Care, & Sleep Medicine. Department of Medicine. Emory University. Atlanta, GA, USA. | pt_BR |
| Affilliation | Malaria Host–Pathogen Interaction Center. Emory Vaccine Center. Yerkes National Primate Research Center. Emory University. Atlanta, GA, USA / Department of Biology. Wake Forest University. Winston-Salem, North Carolina, USA. | pt_BR |
| Affilliation | Malaria Host–Pathogen Interaction Center. Emory Vaccine Center. Yerkes National Primate Research Center. Emory University. Atlanta, GA, USA / School of Chemical & Biomolecular Engineering. Georgia Institute of Technology. Atlanta, GA, USA. | pt_BR |
| Affilliation | Stacey A. Lapp Malaria Host–Pathogen Interaction Center. Emory Vaccine Center. Yerkes National Primate Research Center. Emory University. Atlanta, GA, USA. | pt_BR |
| Affilliation | Malaria Host–Pathogen Interaction Center. Emory Vaccine Center. Yerkes National Primate Research Center. Emory University. Atlanta, GA, USA / Division of Pulmonary, Allergy, Critical Care, & Sleep Medicine. Department of Medicine. Emory University. Atlanta, GA, USA. | pt_BR |
| Affilliation | Division of Pulmonary, Allergy, Critical Care, & Sleep Medicine. Department of Medicine. Emory University. Atlanta, GA, USA. | pt_BR |
| Affilliation | Malaria Host–Pathogen Interaction Center. Emory Vaccine Center. Yerkes National Primate Research Center. Emory University. Atlanta, GA, USA / Institute of Bioinformatics. University of Georgia. Athens, GA, USA. | pt_BR |
| Affilliation | Malaria Host–Pathogen Interaction Center. Emory Vaccine Center. Yerkes National Primate Research Center. Emory University. Atlanta, GA, USA / Institute of Bioinformatics. University of Georgia. Athens, GA, USA. | pt_BR |
| Affilliation | Malaria Host–Pathogen Interaction Center. Emory Vaccine Center. Yerkes National Primate Research Center. Emory University. Atlanta, GA, USA. | pt_BR |
| Affilliation | Malaria Host–Pathogen Interaction Center. Emory Vaccine Center. Yerkes National Primate Research Center. Emory University. Atlanta, GA, USA / Institute of Bioinformatics. University of Georgia. Athens, GA, USA / Department of Genetics. University of Georgia. Athens, GA, USA / Center for Tropical and Emerging Global Diseases. University of Georgia. Athens, GA, USA. | pt_BR |
| Affilliation | Malaria Host–Pathogen Interaction Center. Emory Vaccine Center. Yerkes National Primate Research Center. Emory University. Atlanta, GA, USA / School of Chemical & Biomolecular Engineering. Georgia Institute of Technology. Atlanta, GA, USA. | pt_BR |
| Affilliation | Malaria Host–Pathogen Interaction Center. Emory Vaccine Center. Yerkes National Primate Research Center. Emory University. Atlanta, GA, USA / Division of Pulmonary, Allergy, Critical Care, & Sleep Medicine. Department of Medicine. Emory University. Atlanta, GA, USA / Lowance Center for Human Immunology. Emory University. Atlanta, GA, USA. | pt_BR |
| Affilliation | Malaria Host–Pathogen Interaction Center. Emory Vaccine Center. Yerkes National Primate Research Center. Emory University. Atlanta, GA, USA / Division of Microbiology and Immunology. Department of Pathology. University of Utah. Salt Lake City, UT, USA. | pt_BR |
| Affilliation | Malaria Host–Pathogen Interaction Center. Emory Vaccine Center. Yerkes National Primate Research Center. Emory University. Atlanta, GA, USA / Division of Infectious Diseases. Department of Medicine. Emory University School of Medicine. Atlanta, GA, USA. | pt_BR |
| Subject | Malaria | pt_BR |
| Subject | Plasmodium | pt_BR |
| Embargo date | 2022-01-01 | |
