| Author | Ávila, Andréa Rodrigues | |
| Author | Cabezas-Cruz, Alexjandro | |
| Author | Gissot, Mathieu | |
| Access date | 2020-02-20T19:40:45Z | |
| Available date | 2020-02-20T19:40:45Z | |
| Document date | 2018 | |
| Citation | ÁVILA, Andrea Rodrigues; CABEZAS-CRUZ, Alexjandro; GISSOT, Mathieu. mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway. Parasites & Vectors, v. 11, n. 62, p. 1-9, 2018. | pt_BR |
| ISSN | 1756-3305 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/40110 | |
| Language | por | pt_BR |
| Publisher | BMC | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Apicomplexa | pt_BR |
| Subject in Portuguese | Toxoplasma | pt_BR |
| Title | mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1186/s13071-018-2648-4 | |
| Abstract | Control of gene expression is crucial for parasite survival and is the result of a series of processes that are regulated to permit fine-tuning of gene expression in response to biological changes during the life-cycle of apicomplexan parasites. Control of mRNA nuclear export is a key process in eukaryotic cells but is poorly understood in apicomplexan parasites. Here, we review recent knowledge regarding this process with an emphasis on T. gondii. We describe the presence of divergent orthologs and discuss structural and functional differences in export factors between apicomplexans and other eukaryotic lineages. Undoubtedly, the use of the CRISPR/Cas9 system in high throughput screenings associated with the discovery of mRNA nuclear export complexes by proteomic analysis will contribute to identify these divergent factors. Ligand-based or structure-based strategies may be applied to investigate the potential use of these proteins as targets for new antiprotozoal agents. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil / UMR BIPAR. Animal Health Laboratory. ANSES. INRA. ENVA. Maisons Alfort, Cedex, France. | pt_BR |
| Affilliation | UMR BIPAR. Animal Health Laboratory. ANSES. INRA. ENVA. Maisons Alfort, Cedex, France / Institute of Parasitology. Biology Center. Czech Academy of Sciences. České Budějovice, Czech Republic / Faculty of Science. University of South Bohemia. České Budějovic, Czech Republic. | pt_BR |
| Affilliation | University of Lille. CNRS. Inserm. CHU Lille; Institut Pasteur de Lille. Centre d’Infection et d’Immunité de Lille, Lille, France. | pt_BR |
| Subject | Gene Expression Regulation | pt_BR |
| Subject | Parasites | pt_BR |
| Subject in Spanish | Regulación de la Expresión Génica | pt_BR |
| Subject in Spanish | Parásitos | pt_BR |
| DeCS | Regulação da Expressão Gênica | pt_BR |
| DeCS | Plasmodium | pt_BR |
| DeCS | Cryptosporidium | pt_BR |
| DeCS | Parasitos | pt_BR |
| e-ISSN | 1756-3305 | |
