| Author | Giovanetti, Marta | |
| Author | Benvenuto, Domenico | |
| Author | Angeletti, Silvia | |
| Author | Ciccozzi, Massimo | |
| Access date | 2020-02-29T11:55:54Z | |
| Available date | 2020-02-29T11:55:54Z | |
| Document date | 2020 | |
| Citation | GIOVANETTI, Marta et al. The first two cases of 2019‐nCoV in Italy: Where they come from? Journal of Medical Virology, p. 1-4, Feb. 2020. | pt_BR |
| ISSN | 0146-6615 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/40160 | |
| Description | Devido a pandemia mundial do COVID-19, o artigo da revista foi liberado em acesso aberto durante o ano de 2020, visando divulgação e disseminação. | |
| Description | Em decorrência da pandemia decretada pela OMS em 2020, o artigo encontra-se em acesso aberto. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Epidemiologia | pt_BR |
| Subject in Portuguese | Infecção | pt_BR |
| Subject in Portuguese | Engenharia e Tecnologia | pt_BR |
| Subject in Portuguese | Desenho macromolecular | pt_BR |
| Subject in Portuguese | Coronavírus | pt_BR |
| Subject in Portuguese | COVID-19 | pt_BR |
| Title | The first two cases of 2019‐nCoV in Italy: Where they come from? | pt_BR |
| Type | Article | |
| DOI | 10.1002/jmv.25699 | |
| Abstract | A novel Coronavirus, 2019‐nCoV, has been identified as the causal pathogen of an ongoing epidemic, with the first cases reported in Wuhan, China, last December 2019, and has since spread to other countries worldwide, included Europe and very recently Italy. In this short report, phylogenetic reconstruction was used to better understand the transmission dynamics of the virus from its first introduction in China focusing on the more recent evidence of infection in a couple of Chinese tourists arrived in Italy on 23rd January 2020 and labeled as Coronavirus Italian cases. A maximum clade credibility tree has been built using a dataset of 54 genome sequences of 2019‐nCoV plus two closely related bat strains (SARS‐like CoV) available in GenBank. Bayesian time‐scaled phylogenetic analysis was implemented in BEAST 1.10.4. The Bayesian phylogenetic reconstruction showed that 2019‐2020 nCoV firstly introduced in Wuhan on 25 November 2019, started epidemic transmission reaching many countries worldwide, including Europe and Italy where the two strains isolated dated back 19 January 2020, the same that the Chinese tourists arrived in Italy. Strains isolated outside China were intermixed with strains isolated in China as evidence of likely imported cases in Rome, Italy, and Europe, as well. In conclusion, this report suggests that further spread of 2019‐nCoV epidemic was supported by human mobility and that quarantine of suspected or diagnosed cases is useful to prevent further transmission. Viral genome phylogenetic analysis represents a useful tool for the evaluation of transmission dynamics and preventive action. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University Campus Bio‐Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy. | pt_BR |
| Affilliation | University Campus Bio‐Medico of Rome. Unit of Clinical Laboratory Science. Rome, Italy. | pt_BR |
| Affilliation | University Campus Bio‐Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy. | pt_BR |
| Subject | Epidemiology | pt_BR |
| Subject | Engineering and technology | pt_BR |
| Subject | Infection | pt_BR |
| Subject | Macromolecular design | pt_BR |
| Subject | COVID-19 | pt_BR |
| e-ISSN | 1096-9071 | |
