Author | Rodrigues, Igor A. | |
Author | Ramos, Aline de Souza | |
Author | Falcão, Deborah Q. | |
Author | Ferreira, José Luiz Pinto | |
Author | Basso, Silvia L. | |
Author | Silva, Jefferson Rocha de Andrade | |
Author | Amaral, Ana Claudia Fernandes | |
Access date | 2020-03-02T16:39:50Z | |
Available date | 2020-03-02T16:39:50Z | |
Document date | 2018 | |
Citation | RODRIGUES, Igor A. C. et al. Development of Nanoemulsions to Enhance the Antileishmanial Activity of Copaifera paupera Oleoresins. BioMed Research International, p. 1-10, 2018. | pt_BR |
ISSN | 2314-6141 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/40167 | |
Language | eng | pt_BR |
Rights | open access | pt_BR |
Title | Development of Nanoemulsions to Enhance the Antileishmanial Activity of Copaifera paupera Oleoresins | pt_BR |
Type | Article | pt_BR |
DOI | 10.1155/2018/9781724 | pt_BR |
Abstract | Based on the ethnopharmacological evidences about the antileishmanial activity of Copaifera spp. oleoresins, the effects of crude extracts and fractions of oleoresin of two specimens from Copaifera paupera were evaluated on Leishmania amazonensis and Leishmania infantum strains. The oleoresin rich in α-copaene (38.8%) exhibited the best activity against L. amazonensis (IC50 = 62.5 μg/mL) and against L. infantum (IC50 = 65.9 μg/mL). The sesquiterpene α-copaene isolated was tested alone and exhibited high antileishmanial activity in vitro with IC50 values for L. amazonensis and L. infantum of 17.2 and 11.4 μg/mL, respectively. In order to increase antileishmanial activity, nanoemulsions containing copaiba oleoresin and α-copaene were developed and assayed against L. amazonensis and L. infantum promastigotes. The nanoemulsion containing α-copaene (NANOCOPAEN) showed the best activity against both species, with IC50 of 2.5 and 2.2 μg/mL, respectively. This is the first report about the antileishmanial activity of α-copaene. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Produtos Naturais e Alimentos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Laboratório de Plantas Medicinais e Derivados. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Faculdade de Farmácia. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Laboratório de Plantas Medicinais e Derivados. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Faculdade de Farmácia. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Fundação de Tecnologia do Estado do Acre. Rio Branco, AC, Brasil. | pt_BR |
Affilliation | Universidade Federal do Amazonas. Departamento de Química. Laboratório de Cromatografia. Manaus, AM, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Laboratório de Plantas Medicinais e Derivados. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Nanoemulsions | pt_BR |
Subject | Antileishmanial Activity | pt_BR |
Subject | Copaifera paupera Oleoresins | pt_BR |