| Author | Amorim, Jorge Luis | |
| Author | Figueiredo, Janaína de Barros | |
| Author | Amaral, Ana Claudia Fernandes | |
| Author | Barros, Eliane Gouvêa de Oliveira | |
| Author | Palmero, Célia | |
| Author | Mpalantinos, Maria Athana | |
| Author | Ramos, Aline de Souza | |
| Author | Ferreira, José Luiz Pinto | |
| Author | Silva, Jefferson Rocha de Andrade | |
| Author | Benjamim, Claudia Farias | |
| Author | Basso, Silvia Luciane | |
| Author | Nasciutti, Luiz Eurico | |
| Author | Fernandes, Patricia Dias | |
| Access date | 2020-03-04T15:02:48Z | |
| Available date | 2020-03-04T15:02:48Z | |
| Document date | 2017 | |
| Citation | AMORIM, Jorge Luis et al. Wound healing properties of Copaifera paupera in diabetic mice. PLoS One, v. 12, n. 10, p. 1-14, 2017. | pt_BR |
| ISSN | 1932-6203 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/40201 | |
| Language | eng | pt_BR |
| Rights | open access | pt_BR |
| Title | Wound healing properties of Copaifera paupera in diabetic mice | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1371/journal.pone.0187380 | pt_BR |
| Abstract | Copaifera oleoresin is one of the most used natural products in popular medicine all over the
world. Among other effects (i.e., anti-inflammatory, antinociceptive, microbicidal) one of the
most well-known is its wound healing capacity. However, the mechanism by which the oleoresin presents its effect is still not clear. In this study, our aim was to evaluate the wound
healing capacity of oleoresin obtained from Copaifera paupera, its mechanism of action and
identify its major components. For these purposes, diabetic Swiss Webster mice were topically treated with oleoresin (100, 150 or 200 mg/kg) for 14 consecutive days after an excision was performed in the back of the mice. Cytokines, wound retraction and histological
evaluation were conducted at 3, 7 and 10 days (for cytokines); 0, 3, 7, 10 and 14 days (for
wound retraction); and 7 and 14 days (for histological evaluation). Our data indicate that
oleoresin significantly reduced production of MCP-1 and TNF-α at days 7 and 10 post-excision and increased IL-10 production at both days. All treatments demonstrated an effect
similar or higher to that in collagenase-treated mice. Histological evaluations demonstrated
that higher dose treatment resulted in better resolution and closure of the wound and higher
levels of collagen deposition and indexes of re-epithelialization even when compared with
the collagenase-treated group. The treatment with oleoresin from Copaifera paupera demonstrated that it is even better than an ointment routinely used for improvement of wound
healing, suggesting this oleoresin as an option for use in diabetic patients. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Laboratório de Farmacologia da Dor e da Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Laboratório de Interações Celulares. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Laboratório de Interações Celulares. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Amazonas. Departamento de Química, Laboratório de Cromatografia. Manaus, AM, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Laboratório de Interações Celulares. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Laboratório de Farmacologia da Dor e da Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Wound healing properties | pt_BR |
| Subject | Copaifera paupera | pt_BR |
| Subject | Diabetic mice | pt_BR |
