| Author | Ferreira, Viviane Matos | |
| Author | Ferreira, Ítalo Eustáquio | |
| Author | Chang, How-Yi | |
| Author | Nunes, Amélia Maria Pithon Borges | |
| Author | Topaz, Nadav | |
| Author | Pimentel, Ellen Reis | |
| Author | Moura, Ana Rafaela Silva Simões | |
| Author | Ribeiro, Guilherme de Sousa | |
| Author | Feitosa, Caroline Alves | |
| Author | Reis, Mitermayer Galvão dos | |
| Author | Wang, Xin | |
| Author | Campos, Leila Carvalho | |
| Access date | 2020-03-09T13:38:35Z | |
| Available date | 2020-03-09T13:38:35Z | |
| Document date | 2020 | |
| Citation | FERREIRA, Viviane Matos et al. Meningococcal carriage in young adults six years after meningococcal C conjugate (MCC) vaccine catch-up campaign in Salvador, Brazil. Vaccine, v. 38, p. 2995-3002, 2020. | pt_BR |
| ISSN | 0264-410X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/40250 | |
| Sponsorship | Ethics Committee at the Gonçalo
Moniz Institute, FIOCRUZ-BA (CAEE # 54392116.3.0000.0040) and
was conducted in accordance with good clinical practices | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Neisseria meningitidis | pt_BR |
| Subject in Portuguese | Colonização orofaríngea | pt_BR |
| Subject in Portuguese | Vacina | pt_BR |
| Subject in Portuguese | Doença meningocócica | pt_BR |
| Title | Meningococcal carriage in young adults six years after meningococcal C conjugate (MCC) vaccine catch-up campaign in Salvador, Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.vaccine.2020.02.050 | |
| Abstract | Meningococcal carriage studies are important to improve the knowledge of disease epidemiology as well as to support appropriate vaccination strategies. We conducted a cross-sectional study to determine the prevalence and genotypic characteristics of meningococci collected from young adults in Salvador, Brazil six years after a meningococcal C conjugate vaccine catch-up campaign. From August through November 2016, oropharyngeal swabs were collected from 407 students aged 1824 years attending a private college in Salvador, Brazil. Neisseria meningitidis was identified by standard microbiology methods and real time PCR. Genetic characteristics of meningococci were assessed by rt-PCR and/or whole genome sequencing. We also investigated potential factors associated with carriage. N. meningitidis was detectable in 50 students, 39 by both culture and rt-PCR, 7 by culture alone and 4 by rt-PCR alone, resulting in an overall meningococcal carriage prevalence of 12.3% (50/407). Carriage was independently associated with male sex (adjusted PR: 1.97; 95% CI: 1.12-3.46; p = 0.018) and attending bars or parties at least once per month (aPR: 3.31; 95% CI: 1.49-7.38; p = 0.003). Molecular tests identified 92% (46/50) N. meningitidis as non-groupable, of which 63% (29/46) had the capsule null genotype; 14 NG isolates contained disrupted capsule backbones and belonged to the following genogroups: 7 B, 3 Z, 3 E and 1 W. One isolate belonged to genogroup C tested only by PCR; 3 isolates contained a complete B capsule backbones, 2 of which were determined to be NG by slide agglutination serogrouping. While most meningococcal carriage isolates were non-groupable, there was a high degree of genetic diversity present in the collection, as evidenced by 25 unique STs being detected. The carriage prevalence of meningococcal serogroup C was low among young adults. Continuous vaccination is important to maintain reduced meningococcal carriage and transmission, inducing herd protection. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Centers for Disease Control and Prevention. Atlanta, GA, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Centers for Disease Control and Prevention. Atlanta, GA, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Escola Bahiana de Medicina. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut, United States. | pt_BR |
| Affilliation | Centers for Disease Control and Prevention. Atlanta, GA, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Subject | Neisseria meningitidis | pt_BR |
| Subject | Oropharyngeal colonization | pt_BR |
| Subject | Vaccine | pt_BR |
| Subject | Meningococcal disease | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
