| Author | Hill, Sarah C. | |
| Author | Vasconcellos, Jocelyne | |
| Author | Neto, Zoraima | |
| Author | Jandondo, Domingos | |
| Author | Zé-Zé, Líbia | |
| Author | Aguiar, Renato Santana | |
| Author | Xavier, Jailson | |
| Author | Thezé, Julien | |
| Author | Mirandela, Marinela | |
| Author | Cândido, Ana Luísa Micolo | |
| Author | Vaz, Filipa | |
| Author | Santos, Sebastião Cruz dos | |
| Author | Chieh-Hsi, Wu | |
| Author | U G Kraemer, Moritiz | |
| Author | Melo, Adriana | |
| Author | Schamber-Reis, Bruno L. F. | |
| Author | Azevedo, Girlene S. | |
| Author | Tanuri, Amilcar | |
| Author | Higa, Luiza M. | |
| Author | Clemente, Carina | |
| Author | Silva, Sara Pereira da | |
| Author | Candido, Darlan da Silva | |
| Author | Claro, Inga M. | |
| Author | Quibuco, Domingos | |
| Author | Domigos, Cristovão | |
| Author | Pocongo, Bárbara | |
| Author | Watts, Alexander G. | |
| Author | Khan, Kamran | |
| Author | Alcantara, Luiz Carlos Junior | |
| Author | Sabino, Ester C. | |
| Author | Lackritz, Eve | |
| Author | Pybus, Oliver G. | |
| Author | Alves, Maria João | |
| Author | Afonso, Joana | |
| Author | Faria, Nuno R. | |
| Access date | 2020-03-10T14:56:33Z | |
| Available date | 2020-03-10T14:56:33Z | |
| Document date | 2019 | |
| Citation | HILL, Sarah C. et al. Emergence of the Asian lineage of Zika virus in Angola: an outbreak investigation. The Lancet Infectious Diseases, v. 19, p. 1138-1147, Oct. 2019. | pt_BR |
| ISSN | 1473-3099 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/40274 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Vírus da Zika | pt_BR |
| Subject in Portuguese | Linhagem asiática | pt_BR |
| Subject in Portuguese | Investigação | pt_BR |
| Subject in Portuguese | Surto | pt_BR |
| Subject in Portuguese | Angola | pt_BR |
| Title | Emergence of the Asian lineage of Zika virus in Angola: an outbreak investigation | pt_BR |
| Type | Article | |
| DOI | 10.1016/S1473-3099(19)30293-2 | pt_BR |
| Abstract | Background Zika virus infections and suspected microcephaly cases have been reported in Angola since late 2016, but no data are available about the origins, epidemiology, and diversity of the virus. We aimed to investigate the emergence and circulation of Zika virus in Angola. Methods Diagnostic samples collected by the Angolan Ministry of Health as part of routine arboviral surveillance were tested by real-time reverse transcription PCR by the Instituto Nacional de Investigação em Saúde (Ministry of Health, Luanda, Angola). To identify further samples positive for Zika virus and appropriate for genomic sequencing, we also tested samples from a 2017 study of people with HIV in Luanda. Portable sequencing was used to generate Angolan Zika virus genome sequences from three people positive for Zika virus infection by real-time reverse transcription PCR, including one neonate with microcephaly. Genetic and mobility data were analysed to investigate the date of introduction and geographical origin of Zika virus in Angola. Brain CT and MRI, and serological assays were done on a child with microcephaly to confirm microcephaly and assess previous Zika virus infection. Findings Serum samples from 54 people with suspected acute Zika virus infection, 76 infants with suspected microcephaly, 24 mothers of infants with suspected microcephaly, 336 patients with suspected dengue virus or chikungunya virus infection, and 349 samples from the HIV study were tested by real-time reverse transcription PCR. Four cases identified between December, 2016, and June, 2017, tested positive for Zika virus. Analyses of viral genomic and human mobility data suggest that Zika virus was probably introduced to Angola from Brazil between July, 2015, and June, 2016. This introduction probably initiated local circulation of Zika virus in Angola that continued until at least June, 2017. The infant with microcephaly in whom CT and MRI were done had brain abnormalities consistent with congenital Zika syndrome and serological evidence for Zika virus infection. Interpretation Our analyses show that autochthonous transmission of the Asian lineage of Zika virus has taken place in Africa. Zika virus surveillance and surveillance of associated cases of microcephaly throughout the continent is crucial. Funding Royal Society, Wellcome Trust, Global Challenges Research Fund (UK Research and Innovation), Africa Oxford, John Fell Fund, Oxford Martin School, European Research Council, Departamento de Ciência e Tecnologia/Ministério da Saúde/National Council for Scientific and Technological Development, and Ministério da Educação/Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. | pt_BR |
| Affilliation | University of Oxford. Department of Zoology. Oxford, UK. | pt_BR |
| Affilliation | Ministério da Saúde. Instituto Nacional de Investigação em Saúde. Luanda, Angola. | pt_BR |
| Affilliation | Ministério da Saúde. Instituto Nacional de Investigação em Saúde. Luanda, Angola. | pt_BR |
| Affilliation | Ministério da Saúde. Instituto Nacional de Investigação em Saúde. Luanda, Angola. | pt_BR |
| Affilliation | Instituto Nacional de Saúde Doutor Ricardo Jorge, Águas de Moura, Portugal / Universidade de Lisboa. Faculdade de Ciências. BioISI—Biosystems & Integrative Sciences Institute. Lisbon, Portugal. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | University of Oxford. Department of Zoology. Oxford, UK. | pt_BR |
| Affilliation | Ministério da Saúde. Instituto Nacional de Investigação em Saúde. Luanda, Angola. | pt_BR |
| Affilliation | Ministério da Saúde. Instituto Nacional de Investigação em Saúde. Luanda, Angola. | pt_BR |
| Affilliation | Ministério da Saúde. Instituto Nacional de Investigação em Saúde. Luanda, Angola. | pt_BR |
| Affilliation | Ministério da Saúde. Instituto Nacional de Investigação em Saúde. Luanda, Angola. | pt_BR |
| Affilliation | University of Oxford. Department of Statistics. Oxford, UK. | pt_BR |
| Affilliation | University of Oxford. Department of Zoology. Oxford, UK. | pt_BR |
| Affilliation | Instituto de Pesquisa Professor Joaquim Amorim Neto. Campina Grande, PB, Brasil. | pt_BR |
| Affilliation | Centro Universitário Unifacisa. Campina Grande, PB, Brasil. | pt_BR |
| Affilliation | Instituto de Pesquisa Professor Joaquim Amorim Neto. Campina Grande, PB, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Cligest Clinic. Luanda, Angola. | pt_BR |
| Affilliation | Cligest Clinic. Luanda, Angola. | pt_BR |
| Affilliation | University of Oxford. Department of Zoology. Oxford, UK. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Hospital Pediátrico David Bernardino. Luanda, Angola. | pt_BR |
| Affilliation | Instituto Nacional de Luta Contra SIDA. Luanda, Angola. | pt_BR |
| Affilliation | Instituto Nacional de Luta Contra SIDA. Luanda, Angola. | pt_BR |
| Affilliation | Li Ka Shing Knowledge Institute. St Michael’s Hospital. Toronto, ON, Canada. | pt_BR |
| Affilliation | BlueDot. Toronto, ON, Canada. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavívirus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | WHO. Geneva, Switzerland. | pt_BR |
| Affilliation | University of Oxford. Department of Zoology. Oxford, UK. | pt_BR |
| Affilliation | Instituto Nacional de Saúde Doutor Ricardo Jorge. Águas de Moura, Portugal. | pt_BR |
| Affilliation | Ministério da Saúde. Instituto Nacional de Investigação em Saúde. Luanda, Angola. | pt_BR |
| Affilliation | University of Oxford. Department of Zoology. Oxford, UK. | pt_BR |
| Subject | Zika virus | pt_BR |
| Subject | Asian lineage | pt_BR |
| Subject | Angola | pt_BR |
| Subject | Outbreak | pt_BR |
| Subject | Investigation | pt_BR |
| e-ISSN | 1474-4457 | |
| Embargo date | 2025-01-01 | |
