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AutorBarreda, Nadia Nilda
AutorArriaga Gutiérrez, María Belen
AutorAliaga, Juan Gonzalo
AutorLopez, Kattya
AutorSanabria, Oswaldo Martin
AutorCarmo, Thomas A.
AutorFróes Neto, José F.
AutorLecca, Leonid
AutorAndrade, Bruno de Bezerril
AutorCalderon, Roger I.
Fecha de acceso2020-03-13T13:22:44Z
Fecha de disponibilización2020-03-13T13:22:44Z
Fecha de publicación2020
ReferenciaBARREDA, Nadia Nilda et al. Severe pulmonary radiological manifestations are associated with a distinct biochemical profile in blood of tuberculosis patients with dysglycemia. BMC Infectious Diseases, v. 20, p. 1-14, 2020.pt_BR
ISSN1471-2334pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/40322
PromociónConsejo Nacional de Ciencia, Tecnología e Innovación Tecnológica (CONCYTEC-Peru) / Fondo Nacional de Desarrollo Científico, Tecnológico y de Innovación Tecnológica (FONDECYT, Convenio 173–2015). MBA receives a fellowship from the Fundação de Amparo à Pesquisa da Bahia (FAPESB).pt_BR
Idiomaengpt_BR
EditorBMCpt_BR
Derechos de autoropen accesspt_BR
Palabras clave en PortuguésRadiografia de tóraxpt_BR
Palabras clave en PortuguésHiperglicemiapt_BR
Palabras clave en PortuguésDiabetes mellituspt_BR
Palabras clave en PortuguésPré-diabetespt_BR
Palabras clave en PortuguésTuberculose pulmonarpt_BR
TítuloSevere pulmonary radiological manifestations are associated with a distinct biochemical profile in blood of tuberculosis patients with dysglycemiapt_BR
Tipo del documentoArticlept_BR
DOI10.1186/s12879-020-4843-0
Resumen en InglésDiabetes mellitus (DM) is thought to affect tuberculosis (TB) clinical presentation and treatment response. Whether DM impacts radiological manifestations of pulmonary TB is still not clear. This study investigated the impact of glycemic status on radiological manifestations of pulmonary TB cases and its relationship with concentration of biochemical parameters in peripheral blood. Methods: A retrospective cross-sectional study used data from 132 microbiologically confirmed pulmonary TB patients from Lima, Peru, evaluated in a previous investigation performed between February and December 2017. Chest radiographs were analyzed by a radiologist and a pulmonologist. Radiographic lesions were identified as cavities, alveolar infiltrates and fibrous tracts. Hyperglycemia in TB patients was identified by use of fasting plasma glucose, HbA1c and oral glucose tolerance test. Clinical, biochemical and hematological parameters were also analyzed. Results: TB patients with hyperglycemia presented more frequently with cavities, alveolar infiltrates and fibrous tracts than those with normoglycemia. Hierarchical clustering analysis indicated that patients with more diverse and higher number of lung lesions exhibited a distinct laboratorial profile characterized by heightened white blood cell counts and circulating levels of total cholesterol, triglycerides and transaminases and simultaneously low levels of albumin and hemoglobin. Multivariable regression analyses adjusted for age, sex, prior TB, hemoglobin levels and acid-fast bacilli ≥2+ in sputum smears, demonstrated that presence of prediabetes or diabetes in TB patients was associated with increased odds of having 3 pulmonary lesion types (p = 0.003 and p < 0.01 respectively) or ≥ 4 lesions (p = 0.001 and p = 0.01 respectively). Conclusion: Hyperglycemia (both DM and prediabetes) significantly affected the presentation of radiographic manifestations and the number of lesions in pulmonary TB patients as well as the biochemical profile in peripheral blood.pt_BR
AfiliaciónSocios En Salud Sucursal Peru. Lima, Peru / Universidad Nacional Mayor de San Marcos. Lima, Peru.pt_BR
AfiliaciónUniversidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Fundação José Silveira. Instituto Brasileiro para Investigação da Tuberculose. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil.pt_BR
AfiliaciónSocios En Salud Sucursal Peru. Lima, Peru.pt_BR
AfiliaciónSocios En Salud Sucursal Peru. Lima, Peru / Universidad Nacional Mayor de San Marcos. Lima, Peru / Harvard Medical School. Brigham and Women’s Hospital. Division of Rheumatology, Inflammation, and Immunity. Boston, MA, USA.pt_BR
AfiliaciónSocios En Salud Sucursal Peru. Lima, Peru.pt_BR
AfiliaciónFundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Salvador. Salvador, BA, Brasil.pt_BR
AfiliaciónFundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Salvador. Salvador, BA, Brasil.pt_BR
AfiliaciónSocios En Salud Sucursal Peru. Lima, Perupt_BR
AfiliaciónUniversidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Fundação José Silveira. Instituto Brasileiro para Investigação da Tuberculose. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Salvador. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil.pt_BR
AfiliaciónSocios En Salud Sucursal Peru. Lima, Peru / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil.pt_BR
Palavras clave en InglêsChest x-raypt_BR
Palavras clave en InglêsHyperglycemiapt_BR
Palavras clave en InglêsDiabetes mellituspt_BR
Palavras clave en InglêsPrediabetespt_BR
Palavras clave en InglêsPulmonary tuberculosispt_BR


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