| Author | Carvalho, Eduardo C Nascimento | |
| Author | Vasconcellos, Ângela Gomes | |
| Author | Clarêncio, Jorge | |
| Author | Andrade, Daniela | |
| Author | Barral, Aldina Maria Prado | |
| Author | Barral Netto, Manoel | |
| Author | Carvalho, Cristiana Maria Nascimento | |
| Access date | 2020-03-16T12:33:42Z | |
| Available date | 2020-03-16T12:33:42Z | |
| Document date | 2020 | |
| Citation | CARVALHO, Eduardo C Nascimento et al. Evolution of cytokines/chemokines in cases with community‐acquired pneumonia and distinct etiologies. Pediatric Pulmonology, v. 55, p. 169–176, 2020. | pt_BR |
| ISSN | 8755-6863 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/40341 | |
| Description | Artigo encontra-se disponível em acesso aberto no site do Editor. | pt_BR |
| Sponsorship | Bahia State
Agency for Research Funding (FAPESB; grant no. PNX 0019/2009).
AB, MB‐N, and CMN‐C are senior investigators at the Brazilian
Council for Scientific and Technological Development (CNPq). ECN‐C
was recipient of the CNPq fellowship (163661/2018‐9). | pt_BR |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Infecção respiratória aguda, | pt_BR |
| Subject in Portuguese | criança, | pt_BR |
| Subject in Portuguese | Infecção do trato respiratório inferior | pt_BR |
| Subject in Portuguese | Doença pulmonar | pt_BR |
| Subject in Portuguese | Infecção pneumocócica | pt_BR |
| Title | Evolution of cytokines/chemokines in cases with community-acquired pneumonia and distinct etiologies | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1002/ppul.24533 | |
| Abstract | To compare the systemic cytokines/chemokines levels over time during the evolution of children hospitalized with community-acquired pneumonia (CAP) with and without pneumococcal infection. Methods: Children less than 5‐years‐old hospitalized with CAP were prospectively
investigated in Salvador, Brazil. Clinical data and biological samples were collected to
investigate 20 etiological agents and to determine serum cytokines/chemokines
levels on admission and 2 to 4 weeks later. Cases with pneumococcal infection
received this diagnosis irrespective of also having other etiologies.
Results: A total of 277 patients were enrolled, however, serum sample was unavailable
for cytokine measurement upon admission (n = 61) or upon follow‐up visit (n = 36),
etiology was undetected (n = 50) and one patient did not attend the follow‐up visit.
Therefore, this study group comprised of 129 cases with established etiology. The
median (interquartile range) age and sampling interval was 18 (9‐27) months and 18
(16‐21) days, respectively. Established etiology was viral (52.0%), viral‐bacterial
(30.2%), and bacterial (17.8%). Pneumococcal infection was found in 31 (24.0%)
patients. Overall, median interleukin‐6 (IL‐6; 10.6 [4.7‐30.6] vs 21.0 [20.2‐21.7];
P = .03), IL‐10 (3.5 [3.1‐4.5] vs 20.1 [19.8‐20.4]; P < .001), and CCL2 (19.3 [12.4‐23.2] vs
94.0 [67.2‐117.8]; P < .001) were significantly higher in convalescent serum samples,
whereas median CXCL10 (83.6 [36.4‐182.9] vs 14.6 [0‐116.6]; P < .001) was lower.
Acute vs convalescent levels evolution of IL‐10, CCL2, and CXCL10 did not differ
among patients with or without pneumococcal infection. However, IL‐6 decreased (27.8
[12.3‐48.6] vs 20.8 [20.2‐22.6]; P = .1) in patients with pneumococcal infection and
increased (9.0 [4.2‐22.6] vs 21.0 [20.2‐21.7]; P = .001) in patients without it.
Conclusion: The marked increase of IL‐6 serum levels during the acute phase makes it
a potential biomarker of pneumococcal infection among children with CAP. | pt_BR |
| Affilliation | Bahiana Foundation for Science Development. Bahiana School of Medicine and Public Health. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Federal University of Bahia School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Federal University of Bahia School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brazil / Federal University of Bahia School of Medicine. Department of Pediatrics. Salvador, BA, Brazil. | pt_BR |
| Subject | Acute respiratory infection | pt_BR |
| Subject | Child | pt_BR |
| Subject | Lower respiratory tract infection | pt_BR |
| Subject | Lung disease | pt_BR |
| Subject | Pneumococcal infection | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
