| Author | Souza, Andréa P. de | |
| Author | Oliveira, Gabriel Melo de | |
| Author | Nève, Jean | |
| Author | Vanderpas, Jean | |
| Author | Pirmez, Claude | |
| Author | Castro, Solange L. de | |
| Author | Araujo-Jorge, Tania C. | |
| Author | Rivera, Maria Teresa | |
| Access date | 2020-03-17T14:45:05Z | |
| Available date | 2020-03-17T14:45:05Z | |
| Document date | 2002 | |
| Citation | SOUZA, Andréa P. de Trypanosoma cruzi: host selenium deficiency leads to higher mortality but similar parasitemia in mice. Experimental Parasitology, v. 101, p. 193-199, 2002. | pt_BR |
| ISSN | 0014-4894 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/40357 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Subject in Portuguese | Selênio | pt_BR |
| Subject in Portuguese | Glutationa peroxidase | pt_BR |
| Subject in Portuguese | Isoenzima cardíaca da creatina quinase | pt_BR |
| Title | Trypanosoma cruzi: host selenium deficiency leads to higher mortality but similar parasitemia in mice | pt_BR |
| Type | Article | |
| DOI | 10.1016/S0014-4894(02)00134-0 | |
| Abstract | Selenium is an essential trace element and its deficiency was implicated in heart diseases. We recently showed low Se levels in
chronic chagasic patients with cardiomyopathy. Herein, mice were depleted in Se by feeding the mothers with chow containing only
0.005 mg Se/kg and maintaining this diet for offspring, that were further infected with Trypanosoma cruzi. Survival rate was significantly lower in Se deficient than in control mice. Parasitemia was similar in all groups. Necrotic heart lesions were found after
infection (high CK-MB levels). No outbreaks of parasite growth were detected in chronic survivors submitted or not to a second Se
depletion. The present results confirm our hypothesis that a nutritional deficiency in Se is associated to a higher mortality during T.
cruzi infection. The potential beneficial effect of Se supplementation is a perspective. Hypothesis to explain the higher susceptibility
of Se-depleted mice to T. cruzi infection are discussed. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-estrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-estrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Univ. Libre de Bruxelles. Fac. de Pharmacie. Brussels, Belgium. | pt_BR |
| Affilliation | Hôpital Ambroise-Paré. Mons, Belgium. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-estrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-estrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-estrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Selenium | pt_BR |
| Subject | Glutathione peroxidad | pt_BR |
| Subject | Creatine kinase cardiac isoenzyme | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | Chagas Disease | pt_BR |
| Embargo date | 2025-01-01 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
