Author | Rosa, Regis G. | |
Author | Falavigna, Maicon | |
Author | Robinson, Caroline C. | |
Author | Sanchez, Evelin C. | |
Author | Kochhann, Renata | |
Author | Schneider, Daniel | |
Author | Sganzerla, Daniel | |
Author | Dietrich, Camila | |
Author | Barbosa, Mirceli G. | |
Author | Souza, Denise de | |
Author | Rech, Gabriela S. | |
Author | Santos, Rosa da R. dos | |
Author | Silva, Alice P. da | |
Author | Santos, Mariana M. | |
Author | Dal Lago, Pedro | |
Author | Sharshar, Tarek | |
Author | Bozza, Fernando A. | |
Author | Teixeira, Cassiano | |
Access date | 2020-03-18T18:26:24Z | |
Available date | 2020-03-18T18:26:24Z | |
Document date | 2020 | |
Citation | ROSA, Regis G. et al. Early and Late Mortality Following Discharge From the ICU: A Multicenter Prospective Cohort Study. Critical Care Medicine, v. 48, n. 1, p. 64-72, Jan. 2020. | pt_BR |
ISSN | 0090-3493 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/40390 | |
Description | Quality of Life After ICU Study Group Investigators and the BRICNet. | |
Sponsorship | The present study was funded by the Brazilian Ministry of Health through the Brazilian Unified Health System Institutional Development Program. Drs. Rosa’s, Falavigna’s, Robinson’s, Sanchez’s, Kochhann’s, Schneider’s, Sganzerla’s, Dietrich’s, Barbosa’s, de Souza’s, Rech’s, and dos Santos’s institutions received funding from Brazilian Ministry of Health through the Brazilian Unified Health System Institutional Development Program. Dr Falavigna is manager partner of HTAnalyze, a consulting and training firm in health technology assessment topics. The remaining authors have disclosed that they do not have any potential conflicts of interest. | |
Language | eng | pt_BR |
Publisher | Lippincott, Williams & Wilkins | pt_BR |
Rights | restricted access | pt_BR |
Title | Early and Late Mortality Following Discharge From the ICU: A Multicenter Prospective Cohort Study | pt_BR |
Type | Article | pt_BR |
DOI | 10.1097/CCM.0000000000004024 | |
Abstract | Objectives: To identify the frequency, causes, and risk factors of early and late mortality among general adult patients discharged from ICUs. Design: Multicenter, prospective cohort study. Setting: ICUs of 10 tertiary hospitals in Brazil. Patients: One-thousand five-hundred fifty-four adult ICU survivors with an ICU stay greater than 72 hours for medical and emergency surgical admissions or greater than 120 hours for elective surgical admissions. Interventions: None. Measurements and main results: The main outcomes were early (30 d) and late (31 to 365 d) mortality. Causes of death were extracted from death certificates and medical records. Twelve-month cumulative mortality was 28.2% (439 deaths). The frequency of early mortality was 7.9% (123 deaths), and the frequency of late mortality was 22.3% (316 deaths). Infections were the leading cause of death in both early (47.2%) and late (36.4%) periods. Multivariable analysis identified age greater than or equal to 65 years (hazard ratio, 1.65; p = 0.01), pre-ICU high comorbidity (hazard ratio, 1.59; p = 0.02), pre-ICU physical dependence (hazard ratio, 2.29; p < 0.001), risk of death at ICU admission (hazard ratio per 1% increase, 1.008; p = 0.03), ICU-acquired infections (hazard ratio, 2.25; p < 0.001), and ICU readmission (hazard ratio, 3.76; p < 0.001) as risk factors for early mortality. Age greater than or equal to 65 years (hazard ratio, 1.30; p = 0.03), pre-ICU high comorbidity (hazard ratio, 2.28; p < 0.001), pre-ICU physical dependence (hazard ratio, 2.00; p < 0.001), risk of death at ICU admission (hazard ratio per 1% increase, 1.010; p < 0.001), and ICU readmission (hazard ratios, 4.10, 4.17, and 1.82 for death between 31 and 60 days, 61 and 90 days, and greater than 90 days after ICU discharge, respectively; p < 0.001 for all comparisons) were associated with late mortality. Conclusions: Infections are the main cause of death after ICU discharge. Older age, pre-ICU comorbidities, pre-ICU physical dependence, severity of illness at ICU admission, and ICU readmission are associated with increased risk of early and late mortality, while ICU-acquired infections are associated with increased risk of early mortality. | pt_BR |
Affilliation | Moinhos de Vento Hospital. Intensive Care Unit. Porto Alegre, RS, Brazil / Moinhos de Vento Hospital. Research Projects Office. Porto Alegre, RS, Brazil / Federal University of Health Sciences of Porto Alegre. Post-Graduation Program in Rehabilitation Sciences. Porto Alegre, RS, Brazil. | pt_BR |
Affilliation | Moinhos de Vento Hospital. Research Projects Office. Porto Alegre, RS, Brazil / Federal University of Rio Grande do Sul. Institute for Health Technology Assessment. Postgraduate Program in Epidemiology. Porto Alegre, RS, Brazil / Federal University of Rio Grande do Sul. Postgraduate Program in Epidemiology. Porto Alegre, RS, Brazil. | pt_BR |
Affilliation | Moinhos de Vento Hospital. Research Projects Office. Porto Alegre, RS, Brazil. | pt_BR |
Affilliation | Moinhos de Vento Hospital. Research Projects Office. Porto Alegre, RS, Brazil. | pt_BR |
Affilliation | Moinhos de Vento Hospital. Research Projects Office. Porto Alegre, RS, Brazil. | pt_BR |
Affilliation | Moinhos de Vento Hospital. Research Projects Office. Porto Alegre, RS, Brazil. | pt_BR |
Affilliation | Moinhos de Vento Hospital. Research Projects Office. Porto Alegre, RS, Brazil / Federal University of Rio Grande do Sul. Postgraduate Program in Epidemiology. UFRGS, Porto Alegre, RS, Brazil. | pt_BR |
Affilliation | Moinhos de Vento Hospital. Research Projects Office. Porto Alegre, RS, Brazil. | pt_BR |
Affilliation | Moinhos de Vento Hospital. Research Projects Office. Porto Alegre, RS, Brazil. | pt_BR |
Affilliation | Moinhos de Vento Hospital. Research Projects Office. Porto Alegre, RS, Brazil. | pt_BR |
Affilliation | Moinhos de Vento Hospital. Research Projects Office. Porto Alegre, RS, Brazil. | pt_BR |
Affilliation | Moinhos de Vento Hospital. Research Projects Office. Porto Alegre, RS, Brazil. | pt_BR |
Affilliation | Moinhos de Vento Hospital. Research Projects Office. Porto Alegre, RS, Brazil. | pt_BR |
Affilliation | Moinhos de Vento Hospital. Research Projects Office. Porto Alegre, RS, Brazil. | pt_BR |
Affilliation | Federal University of Health Sciences of Porto Alegre. Post-Graduation Program in Rehabilitation Sciences. Porto Alegre, RS, Brazil. | pt_BR |
Affilliation | University of Versailles Saint-Quentin-en-Yvelines. Raymond Poincaré Hospital. Assistance Publique Hôpitaux of Paris. General Intensive Care. Paris, France. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Medicina Intensiva. Rio de Janeiro, RJ, Brasil / D'Or Institute for Research and Teaching. Department of Critical Care. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Moinhos de Vento Hospital. Intensive Care Unit. Porto Alegre, RS, Brazil / Federal University of Health Sciences of Porto Alegre. Post-Graduation Program in Rehabilitation Sciences. Porto Alegre, RS, Brazil. | pt_BR |
Subject | Cause of death | pt_BR |
Subject | Critical care | pt_BR |
Subject | Critical illness | pt_BR |
Subject | Follow-up studies | pt_BR |
Subject | Mortality | pt_BR |
Subject | Survivors | pt_BR |
e-ISSN | 1530-0293 | |
Embargo date | 2030-12-31 | |