| Author | Ricardo, Debora Decote | |
| Author | Freitas, Isabel Ferreira La Rocque de | |
| Author | Rocha, Juliana Dutra B. | |
| Author | Nascimento, Danielle O. | |
| Author | Nunes, Marise P. | |
| Author | Morrot, Alexandre | |
| Author | Lima, Leonardo Freire de | |
| Author | Previato, Jose Osvaldo | |
| Author | Previato, Lucia Mendonça | |
| Author | Lima, Celio Geraldo Freire de | |
| Access date | 2020-03-19T15:41:09Z | |
| Available date | 2020-03-19T15:41:09Z | |
| Document date | 2019 | |
| Citation | RICARDO, Debora Decote et al. Immunomodulatory role of capsular Polysaccharides constituents of Criptococcus neoformans. Frontiers in Medicine, v. 6, Article 129, 8p, June 2019. | pt_BR |
| ISSN | 2296-858X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/40412 | |
| Language | eng | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Cryptococcus neoformans | pt_BR |
| Subject in Portuguese | Glucuronoxilomanano | pt_BR |
| Subject in Portuguese | Imunomodulação | pt_BR |
| Subject in Portuguese | Evasão imunológica | pt_BR |
| Subject in Portuguese | Galactoxilomanano | pt_BR |
| Title | Immunomodulatory Role of Capsular Polysaccharides Constituents of Cryptococcus neoformans | pt_BR |
| Type | Article | |
| DOI | 10.3389/fmed.2019.00129 | |
| Abstract | Cryptococcosis is a systemic fungal infection caused by Cryptococcus neoformans. In immunocompetent patients, cryptococcal infection is often confined to the lungs. In immunocompromised individuals, C. neoformans may cause life-threatening illness, either from novel exposure or through reactivation of a previously acquired latent infection. For example, cryptococcal meningitis is a severe clinical disease that can manifest in people that are immunocompromised due to AIDS. The major constituents of the Cryptococcus polysaccharide capsule, glucuronoxylomannan (GXM), and galactoxylomannan (GalXM), also known as glucuronoxylomanogalactan (GXMGal), are considered the primary virulence factors of Cryptococcus. Despite the predominance of GXM in the polysaccharide capsule, GalXM has more robust immunomodulatory effects on host cellular immunity. This review summarizes current knowledge regarding host-Crytococcus neoformans interactions and the role of capsular polysaccharides in host immunomodulation. Future studies will likely facilitate a better understanding of the mechanisms involved in antigenic recognition and host immune response to C. neoformans and lead to the development of new therapeutic pathways for cryptococcal infection. | pt_BR |
| Affilliation | Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Seropédica, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Seropédica, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Cryptococcus neoformans | pt_BR |
| Subject | Glucuronoxylomannan (GXM) | pt_BR |
| Subject | Galactoxylomannan (GalXM) | pt_BR |
| Subject | Immunomodulation | pt_BR |
| Subject | Immuno evasion | pt_BR |
