| Author | Soeiro, Maria de Nazaré C. | |
| Author | Mota, Renata Alves | |
| Author | Batista, Denise da Gama Jaen | |
| Author | Meirelles, Maria de Nazareth Leal | |
| Access date | 2020-03-24T19:00:07Z | |
| Available date | 2020-03-24T19:00:07Z | |
| Document date | 2002 | |
| Citation | SOEIRO, Maria Nazaré Correia et al. Endocytic pathway in mouse cardiac cells. Cell Structure and Function, v. 27, p. 469-478, 2002. | pt_BR |
| ISSN | 0386-7196 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/40494 | |
| Language | eng | pt_BR |
| Publisher | Japan Society of Cell Biology | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Cardiomiócitos | pt_BR |
| Subject in Portuguese | Endocitose | pt_BR |
| Subject in Portuguese | Microscopia eletrônica | pt_BR |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Title | Endocytic pathway in mouse cardiac cells | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1247/csf.27.469 | |
| Abstract | Primary cultures of heart muscle cells provide powerful tools for cardiac cell biological research that permits both physiological and biochemical approaches. In the present study we analyzed the endocytosis of cardiac cells and presented morphological characterization of the endocytic machinery using markers, which enabled us to follow the fluid-phase, receptor-mediated endocytosis and the internalization of large particles. Our results demonstrated the route of the internalized cargo to early endosomes followed or not by its discharge in the late compartments. We also confirmed the ability of cardiac muscle cells to ingest large particles such as the mannosylated ligand zymosan A, and even internalize whole eukaryotic cells such as the protozoan parasite Trypanosoma cruzi. Since endocytosis is involved in many important cellular functions, the present work contributes to the knowledge of possible additional roles played by cardiac muscle cells besides their well known ability to act as physically energetic cells in the body, constantly contracting without tiring. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-estrutura e Biologia Celular. Laboratório de Ultra-estrutura Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-estrutura e Biologia Celular. Laboratório de Ultra-estrutura Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Cardiomyocites | pt_BR |
| Subject | Endocytosis | pt_BR |
| Subject | Electron microscopy | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| e-ISSN | 1347-3700 | |
