| Author | Marino, Ana Paula M. P. | |
| Author | Silva, Andréa da | |
| Author | Santos, Paula dos | |
| Author | Pinto, Luzia Maria de Oliveira | |
| Author | Gazzinelli, Ricardo Tostes | |
| Author | Teixeira, Mauro Martins | |
| Author | Lannes-Vieira, Joseli | |
| Access date | 2020-03-25T18:52:45Z | |
| Available date | 2020-03-25T18:52:45Z | |
| Document date | 2004 | |
| Citation | MARINO, Ana Paula M. P. et al. Regulated on Activation, Normal T Cell Expressed and Secreted (RANTES) Antagonist (Met-RANTES) Controls the Early Phase of Trypanosoma cruzi–Elicited Myocarditis. Circulation, v. 110, p. 1443-1449, 2004. | pt_BR |
| ISSN | 0009-7322 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/40513 | |
| Language | eng | pt_BR |
| Publisher | American Heart Association | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Inflamação | pt_BR |
| Subject in Portuguese | Doenças cardíacas | pt_BR |
| Subject in Portuguese | Receptores | pt_BR |
| Subject in Portuguese | Miocardite | pt_BR |
| Subject in Portuguese | Infecção | pt_BR |
| Title | Regulated on activation, normal T cell expressed and secreted (RANTES) antagonist (Met-RANTES) controls the early phase of Trypanosoma cruzi-elicited myocarditis | pt_BR |
| Type | Article | |
| DOI | 10.1161/01.CIR.0000141561.15939.EC | |
| Abstract | Background: Comprehension of the pathogenesis of Trypanosoma cruzi–elicited myocarditis is crucial to delineate strategies aimed at ameliorating the inflammation associated with heart dysfunction. The augmented expression of CC chemokines, especially CCL5/RANTES and CCL3/MIP-1 , in the hearts of infected mice suggests a role for CC chemokines and their receptors in the pathogenesis of T cruzi–elicited myocarditis. Methods and Results: We report that during the early phase of infection in C3H/HeJ mice infected with 100 blood trypomastigotes of T cruzi, most of the inflammatory cells invading the heart tissue were CD8 cells and expressed CCR5, a CCL5/RANTES, and CCL3/MIP1- receptor. Furthermore, peripheral blood CD8 T lymphocytes displayed increased expression of CCR5. These findings led us to use Met-RANTES, a selective CCR1 and CCR5 antagonist, to modulate the acute T cruzi–elicited myocarditis. Met-RANTES treatment did not interfere with parasitism but significantly decreased the numbers of CD4 and CD8 T cells, CCR5 , and interleukin-4 cells invading the heart, paralleling the diminished deposition of fibronectin. Moreover, Met-RANTES treatment resulted in increased survival of infected animals, compared with saline treatment. Conclusions: These results indicate that the massive influx of CCR5 cells into cardiac tissue is not crucial for cell-mediated anti–T cruzi immunity but appears to be critical for pathogenesis of T cruzi–elicited myocarditis. Thus, CC chemokine receptors might become an attractive therapeutic target for further evaluation during T cruzi infection. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Heart disease | pt_BR |
| Subject | Myocarditis | pt_BR |
| Subject | Inflammation | pt_BR |
| Subject | Infection | pt_BR |
| Subject | Receptors | pt_BR |
| e-ISSN | 1524-4539 | |
| Embargo date | 2022-01-01 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
