| Author | Martins, Silvana Ayres | |
| Author | Lannes-Vieira, Joseli | |
| Author | Oliveira, Désio Aurélio Farias de | |
| Author | Brito, José Marques | |
| Author | Villa-Verde, Déa Maria Serra | |
| Author | Savino, Wilson | |
| Access date | 2020-04-12T17:42:37Z | |
| Available date | 2020-04-12T17:42:37Z | |
| Document date | 2004 | |
| Citation | MARTINS, Silvana Ayres et al. Phagocytic cells of the thymic reticulum interact with thymocytes via extracellular matrix ligands and receptors. Cellular Immunology, v. 229, p. 21-30, July 2004. | pt_BR |
| ISSN | 0008-8749 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/40714 | |
| Language | eng | pt_BR |
| Publisher | Elsevier 12 Months | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Integrins | pt_BR |
| Subject in Portuguese | Microambiente tímico | pt_BR |
| Subject in Portuguese | Adesão celular | pt_BR |
| Subject in Portuguese | Células fagocíticas tímicas | pt_BR |
| Subject in Portuguese | Laminina | pt_BR |
| Subject in Portuguese | Fibronectina | pt_BR |
| Subject in Portuguese | Timócitos | pt_BR |
| Title | Phagocytic cells of the thymic reticulum interact with thymocytes via extracellular matrix ligands and receptors | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.cellimm.2004.06.002 | |
| Abstract | We previously showed that, in the context of thymic epithelial cells, thymocyte migration is partially controlled by extracellular
matrix (ECM)-mediated interactions. Herein we evaluated whether these interactions could be involved in cell migration related
events in the context of non-epithelial cells of the thymic microenvironment, the phagocytic cells of the thymic reticulum (PTR). We
first showed, by immunocytochemistry, cytofluorometry, and RT-PCR, that PTR produce ECM components, including fibronectin
and laminin, and express the corresponding integrin-type receptors, VLA-4, VLA-5, and VLA-6. Thymocytes adhere onto PTR
monolayers, with immature CD4þCD8þ cells being predominant. Importantly, such an adhesion is partially mediated by ECM
ligands and receptors, since it was impaired by anti-ECM or anti-ECM receptor antibodies. Conjointly, our data reveal that the
ECM-dependence for thymocyte adhesion onto the thymic microenvironment is not restricted to the epithelial cells, being also seen
when they encounter non-epithelial phagocytic cells. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Universidade Federal de Alagoas. Departamento de Patologia. Maceió, AL, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Autoimunidade e Imunoregulação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Departamento de Histologia e Embriologia. Laboratório de Proliferação e Diferenciação Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Thymic microenvironment | pt_BR |
| Subject | Thymic phagocytic cells | pt_BR |
| Subject | Thymocytes | pt_BR |
| Subject | Fibronectin | pt_BR |
| Subject | Laminin | pt_BR |
| Subject | Integrins | pt_BR |
| Subject | Cell adhesion | pt_BR |
| e-ISSN | 1090-2163 | |
| Embargo date | 2025-01-01 | |
