| Author | Mendoza, Yaxelis | |
| Author | Mewa, Juan Castillo | |
| Author | Martinez, Alexander A. | |
| Author | Zaldivar, Yamitzel | |
| Author | Sosa, Néstor | |
| Author | Arteaga, Griselda | |
| Author | Armién, Blas | |
| Author | Bautista, Christian T. | |
| Author | Garcia-Morales, Claudia | |
| Author | Tapia-Tejo, Daniela | |
| Author | Ávila-Rios, Santiago | |
| Author | Reyes-Terán, Gustavo | |
| Author | Bello, Gonzalo | |
| Author | Pascale, Juan M. | |
| Access date | 2020-04-16T14:24:11Z | |
| Available date | 2020-04-16T14:24:11Z | |
| Document date | 2016 | |
| Citation | MENDOZA, Yaxelis et al. HIV-1 Antiretroviral Drug Resistance Mutations in Treatment Naïve and Experienced Panamanian Subjects: Impact on National Use of EFV-Based Schemes. Plos One, v. 11, n. 4, e015317, 19p, Apr. 2016 | pt_BR |
| ISSN | 1932-6203 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/40802 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | |
| Subject in Portuguese | HIV-1 | pt_BR |
| Subject in Portuguese | Resistência às drogas anti-retrovirais | pt_BR |
| Subject in Portuguese | Panamá | pt_BR |
| Subject in Portuguese | Uso de esquemas baseados em EFV | pt_BR |
| Title | HIV-1 Antiretroviral Drug Resistance Mutations in Treatment Naïve and Experienced Panamanian Subjects: Impact on National Use of EFV-Based Schemes | pt_BR |
| Type | Article | |
| DOI | :10.1371/journal. pone.0154317 | |
| Abstract | The use of antiretroviral therapy in HIV infected subjects prevents AIDS-related illness and
delayed occurrence of death. In Panama, rollout of ART started in 1999 and national coverage has reached 62.8% since then. The objective of this study was to determine the level
and patterns of acquired drug resistance mutations of clinical relevance (ADR-CRM) and
surveillance drug resistance mutations (SDRMs) from 717 HIV-1 pol gene sequences
obtained from 467 ARV drug-experienced and 250 ARV drug-naïve HIV-1 subtypes B
infected subjects during 2007–2013, respectively. The overall prevalence of SDRM and of
ADR-CRM during the study period was 9.2% and 87.6%, respectively. The majority of subjects with ADR-CRM had a pattern of mutations that confer resistance to at least two classes of ARV inhibitors. The non-nucleoside reverse transcriptase inhibitor (NNRTI)
mutations K103N and P225H were more prevalent in both ARV drug-naïve and ARV drugexperienced subjects. The nucleoside reverse transcriptase inhibitor (NRTI) mutation
M184V was more frequent in ARV drug-experienced individuals, while T215YFrev and
M41L were more frequent in ARV drug-naïve subjects. Prevalence of mutations associated
to protease inhibitors (PI) was lower than 4.1% in both types of subjects. Therefore, there is
a high level of resistance (>73%) to Efavirenz/Nevirapine, Lamivudine and Azidothymidine
in ARV drug-experienced subjects, and an intermediate to high level of resistance (5–10%)
to Efavirenz/Nevirapine in ARV drug-naïve subjects. During the study period, we observed
an increasing trend in the prevalence of ADR-CRM in subjects under first-line schemes, but not significant changes in the prevalence of SDRM. These results reinforce the paramount
importance of a national surveillance system of ADR-CRM and SDRM for national management policies of subjects living with HIV. | pt_BR |
| Affilliation | Gorgas Memorial Institute for Health Studies. Direction of Research and Technological Development. Panama City, Panama / Department of Biotechnology, Acharya Nagarjuna University, Guntur City, India / University of Panama. Department of Genetics and Molecular Biology, School of Biology. Panama City, Panama / Institute for Scientific Research and High Technology Services of Panama. Panama City, Panama. | pt_BR |
| Affilliation | Gorgas Memorial Institute for Health Studies. Direction of Research and Technological Development. Panama City, Panama. | pt_BR |
| Affilliation | Gorgas Memorial Institute for Health Studies. Direction of Research and Technological Development. Panama City, Panama / Department of Biotechnology, Acharya Nagarjuna University, Guntur City, India / Institute for Scientific Research and High Technology Services of Panama. Panama City, Panama. | pt_BR |
| Affilliation | Gorgas Memorial Institute for Health Studies. Direction of Research and Technological Development. Panama City, Panama. | pt_BR |
| Affilliation | Gorgas Memorial Institute for Health Studies. Direction of Research and Technological Development. Panama City, Panama. | pt_BR |
| Affilliation | University of Panama. Department of Microbiology, School of Medicine. Panama City, Panama. | pt_BR |
| Affilliation | Gorgas Memorial Institute for Health Studies. Direction of Research and Technological Development. Panama City, Panama / Universidad Interamericana de Panamá. Facultad de Ciencias de la Salud. Panama City, Panama. | pt_BR |
| Affilliation | Gorgas Memorial Institute for Health Studies. Direction of Research and Technological Development. Panama City, Panama. | pt_BR |
| Affilliation | Instituto Nacional de Enfermedades Respiratorias. Centro de Investigación en Enfermedades Infecciosas. Mexico City, Mexico. | pt_BR |
| Affilliation | Instituto Nacional de Enfermedades Respiratorias. Centro de Investigación en Enfermedades Infecciosas. Mexico City, Mexico. | pt_BR |
| Affilliation | Instituto Nacional de Enfermedades Respiratorias. Centro de Investigación en Enfermedades Infecciosas. Mexico City, Mexico. | pt_BR |
| Affilliation | Instituto Nacional de Enfermedades Respiratorias. Centro de Investigación en Enfermedades Infecciosas. Mexico City, Mexico. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Gorgas Memorial Institute for Health Studies. Direction of Research and Technological Development. Panama City, Panama / University of Panama. School of Medicine. Departamento of Microbiology. Panama City, Panama. | pt_BR |
| Subject | HIV-1 | pt_BR |
| Subject | Antiretroviral Drug Resistance | pt_BR |
| Subject | Panama | pt_BR |
| Subject | National Use of EFV-Based Schemes | pt_BR |
