| Author | Conte, Fernando de Paiva | |
| Author | Tinoco, Bianca Corrêa | |
| Author | Chaves, Thiago Santos | |
| Author | Oliveira, Renata Carvalho de | |
| Author | Mansur, Janaina Figueira | |
| Author | Mohana-Borges, Ronaldo | |
| Author | Lemos, Elba Regina S. | |
| Author | Neves, Patricia Cristina da Costa | |
| Author | Silva, Rodrigo Nunes Rodrigues da | |
| Access date | 2020-04-17T13:37:10Z | |
| Available date | 2020-04-17T13:37:10Z | |
| Document date | 2019 | |
| Citation | CONDE, Fernando de Paiva et al. Identification and validation of specific B-cell epitopes of hantaviruses associated to hemorrhagic fever and renal syndrome. PLoS Neglected Tropical Diseases, v. 13, n. 12, p. 1-15, Dec. 2019. | pt_BR |
| ISSN | 1932-2727 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/40818 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Hantavírus | pt_BR |
| Subject in Portuguese | Epítopos de Células B | pt_BR |
| Subject in Portuguese | Febre hemorrágica | pt_BR |
| Subject in Portuguese | Sindrome renal | pt_BR |
| Title | Identification and validation of specific B-cell epitopes of hantaviruses associated to hemorrhagic fever and renal syndrome | pt_BR |
| Type | Article | |
| DOI | 10.1371/journal.pntd.0007915 | |
| Abstract | Orthohantavirus infection is a neglected global health problem affecting approximately 200,000 people/year, spread by rodent hosts and associated to fatal human diseases, such as hemorrhagic fever with renal syndrome (HFRS) and orthohantavirus cardiopulmonary syndrome (HCPS). Circulation of HFRS-associated orthohantaviruses, such as Seoul, Gou, Amur, Dobrava and Hantaan, are supposed to be restricted to Eurasian countries even though their hosts can be a worldwide distribution. Few confirmed HFRS orthohantavirus infections in humans have been reported in American countries, but due to lower medical awareness of the symptoms of this zoonosis, it could be associated to viral underreporting or to misdiagnosis with several tropical hemorrhagic diseases. Serological evidence of orthohantavirus infections, using enzyme-linked immunosorbent assay for the presence of immunoglobulin M and G against recombinant nucleoprotein protein, remains as an essential assay for viral surveillance. In this study, we aimed to identify in silico immunogenic B-cell linear epitopes present on orthohantavirus nucleoprotein that are exclusive to HFRS-related species. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratório de Tecnologia de Anticorpos Monoclonais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratório de Tecnologia de Anticorpos Monoclonais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratório de Tecnologia de Anticorpos Monoclonais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório Genômica Estrutural. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório Genômica Estrutural. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratório de Tecnologia de Anticorpos Monoclonais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratório de Tecnologia de Anticorpos Monoclonais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | B-cell epitopes | pt_BR |
| Subject | Hantaviruses | pt_BR |
| Subject | Hemorrhagic feve | pt_BR |
| Subject | Renal syndrome | pt_BR |
| e-ISSN | 1935-2735 | |
