| Author | Magalhães, Elizabeth S. | |
| Author | Mourao-Sa, Diego S. | |
| Author | Abreu, Adriana Vieira de | |
| Author | Figueredo, Rodrigo T. | |
| Author | Pires, Ana L. | |
| Author | Farias Filho, Francisco A. | |
| Author | Fonseca, Bruna P. F. | |
| Author | Viola, João P. B. | |
| Author | Metz, Christine | |
| Author | Martins, Marco A. | |
| Author | Faria Neto, Hugo Caire C. | |
| Author | Bozza, Patrícia T. | |
| Author | Bozza, Marcelo T. | |
| Access date | 2020-04-20T18:29:13Z | |
| Available date | 2020-04-20T18:29:13Z | |
| Document date | 2007 | |
| Citation | MAGALHÃES, Elizabeth S. et al. Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation. Clinical Immunology, v. 37, p. 1097-1106, 2007. | pt_BR |
| ISSN | 1521-6616 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/40896 | |
| Description | Acesso aberto em 20/04/2020 - https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.200635968 | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Hiper-responsividade das vias aéreas | pt_BR |
| Subject in Portuguese | Asma | pt_BR |
| Subject in Portuguese | Inflamação | pt_BR |
| Subject in Portuguese | Eosinófilos | pt_BR |
| Title | Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation | pt_BR |
| Type | Article | |
| DOI | 10.1002/eji.200635968 | |
| Abstract | Macrophage migration inhibitory factor (MIF) is increased in asthmatic patients and
plays a critical role in the pathogenesis of asthma. We show here that mice lacking MIF
failed to develop airway hyper-responsiveness (AHR), tissue eosinophilia, and mucus
metaplasia. Analysis of the bronchoalveolar fluids revealed a substantial reduction of
IL-13, eotaxin and cysteinyl-leukotrienes. The lack of these cardinal features of asthma
in MIF–/– mice occurs regardless of high concentrations of IL-4 in the lung and OVAspecific IgE in the serum. Antigen-specific lymphocyte proliferation and IL-13
production were similarly increased in the draining lymph nodes of OVA-immunized
and challenged MIF–/– mice compared to WT, but were reduced in the spleen of MIF–/–,
thus indicating differential roles of MIF in these compartments. Stimulation of naive
CD4+ cells with anti-CD3 antibody demonstrated that MIF–/– cells produced increased
amounts of IFN-c and IL-4 compared to WT CD4+ cells. Finally, treatment of sensitized
BALB/c mice with neutralizing anti-MIF antibody abrogated the development of ARH
and airway inflammation without affecting the production of Th2 cytokines or IgE. The
present study demonstrates that MIF is required for allergic inflammation, adding
important elements to our knowledge of asthma pathogenesis and suggesting that
neutralization of MIF might be of therapeutic value in asthma. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Nacional de Câncer. Divisão de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Nacional de Câncer. Divisão de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Institute for Medical Research at North Shore LIJ. Laboratory of Medicinal Biochemistry. Manhasset, NY, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Airway hyper-responsiveness | pt_BR |
| Subject | Asthma | pt_BR |
| Subject | Eosinophils | pt_BR |
| Subject | Inflammation | pt_BR |
| Subject | Th1-Th2 | pt_BR |
| e-ISSN | 1521-7035 | |
