| Author | Tunholi-Alves, Vinícius Menezes | |
| Author | Tunholi, Victor Menezes | |
| Author | Pinheiro, Jairo | |
| Author | Thiengo, Silvana Carvalho | |
| Access date | 2020-04-26T21:23:03Z | |
| Available date | 2020-04-26T21:23:03Z | |
| Document date | 2012 | |
| Citation | TUNHOLI-ALVES, Vinícius Menezes et al. Effects of infection byl arvae of Angiostrongylus cantonensis (Nematoda,Metastrongylidae)on th emetabolism of the experimental intermediate host Biomphalaria glabrata. Experimental Parasitology, v. 131, p. 143-147, Mar. 2012. | pt_BR |
| ISSN | 0014-4894 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/40974 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Biomphalaria glabrata | pt_BR |
| Subject in Portuguese | Angiostrongylus cantonensis | pt_BR |
| Subject in Portuguese | Mudanças bioquímicas | pt_BR |
| Subject in Portuguese | Relação hospedeira-parasita | pt_BR |
| Title | Effects of infection by larvae of Angiostrongylus cantonensis (Nematoda, Metastrongylidae) on the metabolism of the experimental intermediate host Biomphalaria glabrata | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.exppara.2012.03.003 | |
| Abstract | The effect of infection by Angiostrongylus cantonensis on the activity of the enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and the concentration of total proteins, uric acid and urea in the hemolymph of Biomphalaria glabrata were investigated. The snails were dissected after 1, 2 and 3 weeks of infection to collect the hemolymph. The infection by A. cantonensis induced severe changes in the host snail's metabolism, triggering physiological mechanisms to minimize the deleterious effects caused by the larvae. There was a significant decrease in the concentration of total proteins in the infected snails, which occurred gradually as the infection advanced. This change was accompanied by an increase in the concentrations of urea and a decrease in the levels of uric acid in the hemolymph, suggesting that in this model the infection induces proteolysis and inversion of the excretion pattern of the infected snails. Besides this, variations in the activities of the aminotransferases were observed, with significantly higher levels in the infected groups than in the control group. These results indicate an increase in the protein metabolism of the infected snails, since there was an increase in nitrogen catabolites such as urea. | pt_BR |
| Affilliation | Universidade Federal Rural do Rio de Janeiro. Instituto de Biologia. Departamento de Ciências Fisiológicas. Seropédica, RJ, Brasil / Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Departamento de Parasitologia Animal. Curso de Pós-Graduação em Ciências Veterinárias. Seropédica, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Rural do Rio de Janeiro. Instituto de Biologia. Departamento de Ciências Fisiológicas. Seropédica, RJ, Brasil / Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Departamento de Parasitologia Animal. Curso de Pós-Graduação em Ciências Veterinárias. Seropédica, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Rural do Rio de Janeiro. Instituto de Biologia. Departamento de Ciências Fisiológicas. Seropédica, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Nacional de Referência em Malacologia Médica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Host–parasite relationship | pt_BR |
| Subject | Biomphalaria glabrata | pt_BR |
| Subject | Angiostrongylus cantonensis | pt_BR |
| Subject | Biochemical changes | pt_BR |
| e-ISSN | 1090-2449 | |
| Embargo date | 2022-01-01 | |
