| Author | Fernandes, Rosilainy S. | |
| Author | Bersot, Maria I. | |
| Author | Castro, Marcia G. | |
| Author | Telleria, Erich Loza | |
| Author | Brito, Anielly Ferreira de | |
| Author | Raphael, Lidiane M. | |
| Author | Bonaldo, Myrna C. | |
| Author | Oliveira, Ricardo Lourenço de | |
| Access date | 2020-05-03T17:43:51Z | |
| Available date | 2020-05-03T17:43:51Z | |
| Document date | 2019 | |
| Citation | FERNANDES, Rosilainy S. et al. Low vector competence in sylvatic mosquitoes limits Zika virus to initiate an enzootic cycle in South America. Scientific Reports, v. 9, p. 1-7, 2019. | pt_BR |
| ISSN | 2045-2322 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/41071 | |
| Language | eng | pt_BR |
| Publisher | Nature Research | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Zika virus | pt_BR |
| Subject in Portuguese | Mosquitos silvestres | pt_BR |
| Subject in Portuguese | Baixa competência vetorial | pt_BR |
| Subject in Portuguese | Ciclo enzoótico | pt_BR |
| Subject in Portuguese | América do Sul | pt_BR |
| Title | Low vector competence in sylvatic mosquitoes limits Zika virus to initiate an enzootic cycle in South America | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1038/s41598-019-56669-4 | |
| Abstract | Zika virus (ZIKV) has spread in the Americas since 2015 and the potential establishment of a sylvatic transmission cycle in the continent has been hypothesized. We evaluated vector competence of five sylvatic Neotropical mosquito species to two ZIKV isolates. Distinct batches of Haemagogus leucoceleanus, Sabethes albiprivus, Sabethes identicus, Aedes terrens and Aedes scapularis females were respectively orally challenged and inoculated intrathoracically with ZIKV. Orally challenged mosquitoes were refractory or exhibited low infection rates. Viral dissemination was detected only in Hg. leucocelaenus, but with very low rates. Virus was not detected in saliva of any mosquito orally challenged with ZIKV, regardless of viral isolate and incubation time. When intrathoracically injected, ZIKV disseminated in high rates in Hg. leucocelaenus, Sa. identicus and Sa. albpiprivus, but low transmission was detected in these species; very low dissemination and no transmission was detected in Ae. terrens and Ae. scapularis. Together these results suggest that genetically determined tissue barriers, especially in the midgut, play a vital role in inhibiting ZIKV for transmission in the tested sylvatic mosquito species. Thus, an independent enzootic transmission cycle for ZIKV in South America is very unlikely. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil / Charles University. Faculty of Science. Department of Parasitology. Prague, Czech Republic. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Zika virus | pt_BR |
| Subject | Low vector competence | pt_BR |
| Subject | Sylvatic mosquitoes | pt_BR |
| Subject | enzootic cycle | pt_BR |
| Subject | South America | pt_BR |
