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| Autor | Penido, Carmen | |
| Autor | Abreu, Adriana Vieira de | |
| Autor | Bozza, Marcelo T. | |
| Autor | Faria Neto, Hugo Caire C. | |
| Autor | Bozza, Patrícia T. | |
| Fecha de acceso | 2020-05-03T18:42:02Z | |
| Fecha de disponibilización | 2020-05-03T18:42:02Z | |
| Fecha de publicación | 2003 | |
| Referencia | PENIDO, Carmen et al. Role of Monocyte Chemotactic Protein-1/CC Chemokine Ligand 2 on T Lymphocyte Trafficking during Inflammation Induced by Lipopolysaccharide or Mycobacterium bovis Bacille Calmette-Guérin. Journal of Immunology, v. 171, p. 6788-6794, 2003. | pt_BR |
| ISSN | 0022-1767 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/41073 | |
| Descripción | Acesso aberto em 03/05/2020 - https://www.jimmunol.org/content/171/12/6788 | pt_BR |
| Idioma | eng | pt_BR |
| Editor | American Association of Immunologists | pt_BR |
| Derechos de autor | open access | |
| Palabras clave en Portugués | Mycobacterium bovis | pt_BR |
| Palabras clave en Portugués | Lipopolysaccharide | pt_BR |
| Palabras clave en Portugués | Bacille Calmette-Guérin | pt_BR |
| Palabras clave en Portugués | Quimiocina da proteína quimiotática-1 de monócitos / CC | pt_BR |
| Palabras clave en Portugués | Linfócitos T | pt_BR |
| Palabras clave en Portugués | Inflamação | pt_BR |
| Título | Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guérin | pt_BR |
| Tipo del documento | Article | |
| DOI | 10.4049/jimmunol.171.12.6788 | |
| Resumen en Inglés | Gammadelta T lymphocytes are involved in a great variety of inflammatory and infectious responses. However, the mechanisms by which gammadelta T lymphocytes migrate to inflamed sites are poorly understood. In this study we investigate the role of monocyte chemotactic protein (MCP)-1 in regulating gammadelta T cell migration after LPS or Mycobacterium bovis bacille Calmette-Guérin (BCG) challenge. LPS-induced gammadelta T cell influx was significantly inhibited by either pretreatment with dexamethasone or vaccinia virus Lister 35-kDa chemokine binding protein, vCKBP, a CC chemokine neutralizing protein, suggesting a role for CC chemokines in this phenomenon. LPS stimulation increased the expression of MCP-1 mRNA and protein at the inflammation site within 6 h. It is noteworthy that LPS was unable to increase MCP-1 production or gammadelta T cell recruitment in C3H/HeJ, indicative of the involvement of Toll-like receptor 4. Gammadelta T cells express MCP-1 receptor CCR2. Pretreatment with anti-MCP-1 mAb drastically inhibited LPS-induced in vivo gammadelta T cell mobilization. Indeed, MCP-1 knockout mice were unable to recruit gammadelta T cells to the pleural cavity after LPS stimulation, effect that could be restored by coadministration of MCP-1. In addition, BCG-induced gammadelta lymphocyte accumulation was significantly reduced in MCP-1 knockout mice when compared with wild-type mice. In conclusion, our results indicate that LPS-induced gammadelta T lymphocyte migration is dependent on Toll-like receptor 4 and sensitive to both dexamethasone and CC chemokine-binding protein inhibition. Moreover, by using MCP-1 neutralizing Abs and genetically deficient mice we show that LPS- and BCG-induced gammadelta T lymphocyte influx to the pleural cavity of mice is mainly orchestrated by the CC chemokine MCP-1. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliación | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Palavras clave en Inglês | Mycobacterium bovis | pt_BR |
| Palavras clave en Inglês | Lipopolysaccharide | pt_BR |
| Palavras clave en Inglês | Bacille Calmette-Guérin | pt_BR |
| Palavras clave en Inglês | Chemotactic Protein-1/CC Chemokine | pt_BR |
| Palavras clave en Inglês | Inflammation | pt_BR |
| Palavras clave en Inglês | T Lymphocyte Trafficking | pt_BR |
| e-ISSN | 1550-6606 | |
| xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero |
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