| Author | Hernandez, Nicholas | |
| Author | Bucciol, Giorgia | |
| Author | Moens, Leen | |
| Author | Le Pen, Jérémie | |
| Author | Shahrooei, Mohammad | |
| Author | Goudouris, Ekaterini | |
| Author | Shirkani, Afshin | |
| Author | Changi-Ashtiani, Majid | |
| Author | Rokni-Zadeh, Hassan | |
| Author | Sayar, Esra Hazar | |
| Author | Reisli, Ismail | |
| Author | Lefevre-Utile, Alain | |
| Author | Zijlmans, Dick | |
| Author | Jurado, Andrea | |
| Author | Pholien, Ruben | |
| Author | Drutman, Scott | |
| Author | Belkaya, Serkan | |
| Author | Cobat, Aurelie | |
| Author | Boudewijns, Robbert | |
| Author | Jochmans, Dirk | |
| Author | Neyts, Johan | |
| Author | Seeleuthner, Yoann | |
| Author | Lorenzo-Diaz, Lazaro | |
| Author | Enemchukwu, Chibuzo | |
| Author | Tietjen, Ian | |
| Author | Hoffmann, Hans-Heinrich | |
| Author | Momenilandi, Mana | |
| Author | Pöyhönen, Laura | |
| Author | Siqueira, Marilda Agudo Mendonça Teixeira de | |
| Author | Lima, Sheila M Barbosa de | |
| Author | Matos, Denise C. de Souza | |
| Author | Homma, Akira | |
| Author | Maia, Maria de Lourdes S. | |
| Author | Barros, Tamiris Azamor da Costa | |
| Author | Oliveira, Patricia Mouta Nunes de | |
| Author | Mesquita, Emersom Ciclini | |
| Author | Gijsbers, Rik | |
| Author | Zhang, Shen-Ying | |
| Author | Seligman, Stephen J. | |
| Author | Abel, Laurent | |
| Author | Hertzog, Paul | |
| Author | Marr, Nico | |
| Author | Martins, Reinaldo de Menezes | |
| Author | Meyts, Isabelle | |
| Author | Zhang, Qian | |
| Author | MacDonald, Margaret R. | |
| Author | Rice, Charles M. | |
| Author | Casanova, Jean-Laurent | |
| Author | Jouanguy, Emmanuelle | |
| Author | Bossuyt, Xavier | |
| Access date | 2020-05-05T17:30:12Z | |
| Available date | 2020-05-05T17:30:12Z | |
| Document date | 2019 | |
| Citation | HERNANDEZ, Nicholas et al. Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines. J. Exp. Med., v. 216, n. 9, p. 2057-2070, 2019. | pt_BR |
| ISSN | 0022-1007 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/41120 | |
| Description | Acesso aberto em 05/05/2020 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719432/pdf/JEM_20182295.pdf | pt_BR |
| Language | eng | pt_BR |
| Publisher | Rockefeller University Press | pt_BR |
| Rights | open access | |
| Title | Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines | pt_BR |
| Type | Article | |
| DOI | 10.1084/jem.20182295 | |
| Abstract | Vaccination against measles, mumps, and rubella (MMR) and yellow fever (YF) with live attenuated viruses can rarely cause life-threatening disease. Severe illness by MMR vaccines can be caused by inborn errors of type I and/or III interferon (IFN) immunity (mutations in IFNAR2, STAT1, or STAT2). Adverse reactions to the YF vaccine have remained unexplained. We report two otherwise healthy patients, a 9-yr-old boy in Iran with severe measles vaccine disease at 1 yr and a 14-yr-old girl in Brazil with viscerotropic disease caused by the YF vaccine at 12 yr. The Iranian patient is homozygous and the Brazilian patient compound heterozygous for loss-of-function IFNAR1 variations. Patient-derived fibroblasts are susceptible to viruses, including the YF and measles virus vaccine strains, in the absence or presence of exogenous type I IFN. The patients' fibroblast phenotypes are rescued with WT IFNAR1 Autosomal recessive, complete IFNAR1 deficiency can result in life-threatening complications of vaccination with live attenuated measles and YF viruses in previously healthy individuals. | pt_BR |
| Affilliation | St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. Rockefeller University, New York, NY, USA. | pt_BR |
| Affilliation | Laboratory of Inborn Errors of Immunity, Department of Immunology, Microbiology and Transplantation, KU Leuven, Leuven, Belgium. | pt_BR |
| Affilliation | Laboratory of Inborn Errors of Immunity, Department of Immunology, Microbiology and Transplantation, KU Leuven, Leuven, Belgium. | pt_BR |
| Affilliation | The Rockefeller University. Laboratory of Virology and Infectious Disease. New York, NY, USA. | pt_BR |
| Affilliation | Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex. Ahvaz, Iran / Department of Microbiology and Immunology. Clinical and Diagnostic Immunology. KU Leuven, Leuven, Belgium. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Allergy and Clinical Immunology Department, Bushehr University of Medical Science, School of Medicine, Bushehr, Iran. | pt_BR |
| Affilliation | School of Mathematics, Institute for Research in Fundamental Sciences. Tehran, Iran. | pt_BR |
| Affilliation | Department of Medical Biotechnology, School of Medicine, Zanjan University of Medical Sciences. Zanjan, Iran. | pt_BR |
| Affilliation | Department of Pediatrics, Division of Pediatric Immunology and Allergy, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey. | pt_BR |
| Affilliation | Department of Pediatrics, Division of Pediatric Immunology and Allergy, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey. | pt_BR |
| Affilliation | Pediatrics Department, Jean Verdier Hospital, Assistance Publique des Hopitaux de Paris, Paris 13, University, Bondy, France. | pt_BR |
| Affilliation | The Rockefeller University. Laboratory of Virology and Infectious Disease. New York, NY, USA. | pt_BR |
| Affilliation | The Rockefeller University. Laboratory of Virology and Infectious Disease. New York, NY, USA. | pt_BR |
| Affilliation | Laboratory of Virology and Chemotherapy, Department of Microbiology and Immunology, Rega Institute for Medical Research. KU Leuven, Leuven, Belgium. | pt_BR |
| Affilliation | St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. Rockefeller University, New York, NY, USA. | pt_BR |
| Affilliation | St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. Rockefeller University, New York, NY, USA. | pt_BR |
| Affilliation | Pediatric Immunology-Hematology Unit, Assistance Publique-Hopitaux de Paris, Necker Hospital for Sick Children, Paris, France. | pt_BR |
| Affilliation | Laboratory of Virology and Chemotherapy, Department of Microbiology and Immunology, Rega Institute for Medical Research. KU Leuven, Leuven, Belgium. | pt_BR |
| Affilliation | Laboratory of Virology and Chemotherapy, Department of Microbiology and Immunology, Rega Institute for Medical Research. KU Leuven, Leuven, Belgium. | pt_BR |
| Affilliation | Laboratory of Virology and Chemotherapy, Department of Microbiology and Immunology, Rega Institute for Medical Research. KU Leuven, Leuven, Belgium. | pt_BR |
| Affilliation | Paris Descartes University, Imagine Institute. Paris, France / Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sante et de la Recherche Médicale U1163. Paris, France. | pt_BR |
| Affilliation | Paris Descartes University, Imagine Institute. Paris, France / Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sante et de la Recherche Médicale U1163. Paris, France. | pt_BR |
| Affilliation | The Rockefeller University. Laboratory of Virology and Infectious Disease. New York, NY, USA. | pt_BR |
| Affilliation | The Rockefeller University. Laboratory of Virology and Infectious Disease. New York, NY, USA. | pt_BR |
| Affilliation | The Rockefeller University. Laboratory of Virology and Infectious Disease. New York, NY, USA. | pt_BR |
| Affilliation | Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. | pt_BR |
| Affilliation | St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. Rockefeller University, New York, NY, USA. | pt_BR |
| Affilliation | Ministério da Saúde. Fundação Oswaldo Cruz. Instituto Osvaldo Cruz. Laboratório Nacional de Referência em Vírus Respiratório. Rio de Janeiro, RJ, Brasil. . | pt_BR |
| Affilliation | Ministério da Saúde. Fundação Oswaldo Cruz. Bio-Manguinhos. Laboratório de Técnicas Virológicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Ministério da Saúde. Fundação Oswaldo Cruz. Bio-Manguinhos. Laboratório de Técnicas Imunológicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Ministério da Saúde. Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Ministério da Saúde. Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Ministério da Saúde. Fundação Oswaldo Cruz. Bio-Manguinhos. Laboratório de Técnicas Imunológicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Ministério da Saúde. Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Ministério da Saúde. Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Laboratory for Viral Vector Technology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium / Leuven Viral Vector Core, Leuven, Belgium. | pt_BR |
| Affilliation | St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. Rockefeller University, New York, NY, USA / Paris Descartes University, Imagine Institute, Paris, France / Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sante et de la Recherche Médicale U1163, Paris, France. | pt_BR |
| Affilliation | St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. Rockefeller University, New York, NY, USA / Laboratory of Inborn Errors of Immunity, Department of Immunology, Microbiology and Transplantation, KU Leuven, Leuven, Belgium.. | pt_BR |
| Affilliation | St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. Rockefeller University, New York, NY, USA / Paris Descartes University, Imagine Institute, Paris, France / Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sante et de la Recherche Médicale U1163, Paris, France. | pt_BR |
| Affilliation | Hudson Institute of Medical Research. Clayton, Victoria, Australia. | pt_BR |
| Affilliation | Division of Translational Medicine, Sidra Medicine, Doha, Qatar / College of Health and Life Sciences, Hamad Bin Khalifa University. Doha, Qatar. | pt_BR |
| Affilliation | Ministério da Saúde. Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Laboratory of Inborn Errors of Immunity, Department of Immunology, Microbiology and Transplantation. KU Leuven, Leuven, Belgium / Department of Pediatrics, University Hospitals. Leuven, Leuven, Belgium. | pt_BR |
| Affilliation | 7Precision Immunology Institute and Mindich Child Health and Development Institute at the Icahn School of Medicine at Mount Sinai. New York, NY, USA. | pt_BR |
| Affilliation | St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. Rockefeller University, New York, NY, USA. | pt_BR |
| Affilliation | Precision Immunology Institute and Mindich Child Health and Development Institute at the Icahn School of Medicine at Mount Sinai, New York, NY | pt_BR |
| Affilliation | St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. Rockefeller University, New York, NY, USA. | pt_BR |
| Affilliation | Laboratory of Virology and Infectious Disease. The Rockefeller University, New York, NY, USA. | pt_BR |
| Affilliation | Laboratory of Virology and Infectious Disease. The Rockefeller University, New York, NY, USA. | pt_BR |
| Affilliation | St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. Rockefeller University, New York, NY, USA / Pediatric Immunology-Hematology Unit, Assistance Publique-Hopitaux de Paris, Necker Hospital for Sick Children, Paris, France / Paris Descartes University, Imagine Institute, Paris, France / Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sante et de la Recherche Médicale ´ U1163, Paris, France / Howard Hughes Medical Institute New York, NY, USA. | pt_BR |
| Affilliation | St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. Rockefeller University, New York, NY, USA / Paris Descartes University, Imagine Institute, Paris, France / Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sante et de la Recherche M ´ edicale ´ U1163, Paris, France. | pt_BR |
| Affilliation | Department of Microbiology, Immunology and Transplantation, Clinical and Diagnostic Immunology. KU Leuven, Leuven, Belgium. | pt_BR |
| Affilliation | Department of Laboratory Medicine, University Hospitals Leuven. Leuven, Belgium. | pt_BR |
| e-ISSN | 1540-9538 | |
