| Author | Melgaço, Juliana Gil | |
| Author | Azamor, Tamiris | |
| Author | Bom, Ana Paula Dinis Ano | |
| Access date | 2020-05-06T00:00:34Z | |
| Available date | 2020-05-06T00:00:34Z | |
| Document date | 2020 | |
| Citation | MELGAÇO, Juliana Gil; AZAMOR, Tamiris; BOM, Ana Paula Dinis Ano. Protective immunity after COVID-19 has been questioned: what can we do without SARS-CoV-2-IgG detection? Cellular Immunology, p. 1-7, Apr. 28 2020. | |
| ISSN | 0008-8749 | |
| URI | https://www.arca.fiocruz.br/handle/icict/41132 | |
| Language | eng | en_US |
| Publisher | Elsevier | |
| Later version | https://www.arca.fiocruz.br/handle/icict/51490 | |
| Rights | open access | |
| Subject in Portuguese | Coronavírus | pt_BR |
| Subject in Portuguese | COVID-19 | pt_BR |
| Subject in Portuguese | SARS-CoV-2-IgG | pt_BR |
| Title | Protective immunity after COVID-19 has been questioned: what can we do without SARS-CoV-2-IgG detection? | en_US |
| Type | Preprint | |
| DOI | 10.1016/j.cellimm.2020.104114 | |
| Abstract | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a severe acute respiratory syndrome that is called COVID-19. Clinical manifestations of COVID-19 include diarrhea, pneumonia, lymphopenia, exhausted lymphocytes, and pro-inflammatory cytokine production. Immunology is part of the process of clinical evolution, but there are some questions around immunity-based protection: (1) why some infected people have only mild symptoms of the disease or are asymptomatic; (2) why delayed and weak antibody responses are associated with severe outcomes; and (3) why positivity in molecular tests does not represent protective antibody IgG. Perhaps T cell responses may be the key to solving those questions. SARS-CoV-2-specific memory T cells persist in peripheral blood and may be capable of providing effective information about protective immunity. The T cells studies can be helpful in elucidating the pathways for development of vaccines, therapies, and diagnostics for COVID-19 and for filling these immunology knowledge gaps. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Immunobiological Technology Institute (Bio-Manguinhos). Laboratory of Immunological Technology. Rio de Janeiro, RJ, Brazil. | |
| Affilliation | Oswaldo Cruz Foundation. Immunobiological Technology Institute (Bio-Manguinhos). Laboratory of Immunological Technology. Rio de Janeiro, RJ, Brazil. | |
| Affilliation | Oswaldo Cruz Foundation. Immunobiological Technology Institute (Bio-Manguinhos). Laboratory of Immunological Technology. Rio de Janeiro, RJ, Brazil. | |
| Subject | Coronavirus | en_US |
| Subject | COVID-19 | en_US |
| Subject | SARS-CoV-2-IgG | en_US |
