| Autor | Cruz, Daniella Arêas Mendes da | |
| Autor | Meis, Juliana de | |
| Autor | Almeida, Vinicius Cotta de | |
| Autor | Savino, Wilson | |
| Data de acesso | 2020-05-06T17:41:23Z | |
| Data de disponibilização | 2020-05-06T17:41:23Z | |
| Data do publicação | 2003 | |
| Citação | CRUZ, Daniela Arês Mendes da et al. Experimental Trypanosoma cruzi infection alters the shaping of the central and peripheral T-cell repertoire. Microbes and Infection, v. 5, p. 825-832, 2003. | pt_BR |
| ISSN | 1286-4579 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/41138 | |
| Idioma | eng | pt_BR |
| Editor | Elsevier | pt_BR |
| Direito Autoral | restricted access | |
| Palavras-chave | Trypanosoma cruzi | pt_BR |
| Palavras-chave | Infecção experimental | pt_BR |
| Palavras-chave | Células T | pt_BR |
| Palavras-chave | Repertório central e periférico | pt_BR |
| Título | Experimental Trypanosoma cruzi infection alters the shaping of the central and peripheral T-cell repertoire | pt_BR |
| Tipo do documento | Article | |
| DOI | 10.1016/S1286-4579(03)00156-4 | |
| Resumo em Inglês | We investigated the thymic and peripheral T-lymphocyte subsets in BALB/c mice undergoing acute or chronic Trypanosoma cruzi
infection, in terms of expression of particular Vb rearrangements of the T-cell receptor. We first confirmed the severe depletion of CD4+
CD8+
thymocytes following acute T. cruzi infection. By contrast, the numbers of CD4+
CD8+ cells in subcutaneous lymph nodes increased up to 16
times. In subcutaneous lymph nodes, we found CD4+
CD8+ cells that expressed prohibited segments TCRVb5 and TCRVb12 (which are
physiologically deleted in the thymus of BALB/c mice), as did some mature single-positive cells (CD4+
CD8– and CD4–
CD8+
). In the thymus
of infected animals, although higher numbers of immature cells bearing such Vb segments were seen, they were no longer detected in the
mature single-positive stage, suggesting that negative selection occurs normally. We also found increased numbers of cells bearing the
potentially autoreactive phenotype TCRVb5+ and TCRVb12+ in T-lymphocyte subsets from subcutaneous lymph nodes of T. cruzi chronically
infected mice. In conclusion, our data indicate that immature T lymphocytes bearing prohibited TCRVb segments leave the thymus and gain
the lymph nodes, where they further differentiate into mature CD4+ or CD8+ cells. Conjointly, these findings show changes in the shaping of
the central and peripheral T-cell repertoire in both acute and chronic phases of murine T. cruzi infection. The release of potentially autoreactive
T cells in the periphery of the immune system may contribute to the autoimmune process found in both murine and human Chagas’ disease. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celuar. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Palavras-chave em inglês | Trypanosoma cruzi | pt_BR |
| Palavras-chave em inglês | Experimental Infection | pt_BR |
| Palavras-chave em inglês | T Cells | pt_BR |
| Palavras-chave em inglês | Central and peripheral repertoire | pt_BR |
| e-ISSN | 1769-714X | |
| Data de embargo | 2022-01-01 | |
