Author | Freitas, Silvia Regina Sampaio | |
Author | Cabello, Pedro Hernan | |
Author | Moura Neto, Rodrigo Soares | |
Author | Dolinsky, Luciana Cresta | |
Author | Bóia, Márcio Neves | |
Access date | 2020-05-11T18:50:49Z | |
Available date | 2020-05-11T18:50:49Z | |
Document date | 2007 | |
Citation | FREITAS, Silvia Regina Sampaio et al. Combined Analysis of Genetic and Environmental Factors on Essential Hypertension in a Brazilian Rural Population in the Amazon Region. Arquivos Brasileiros de Cardiologia, São Paulo, v. 88, n. 4, p. 393-397, 2007. | pt_BR |
ISSN | 0066-782X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/41189 | |
Language | eng | pt_BR |
Publisher | Sociedade Brasileira de Cardiologia | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Polimorfismos | pt_BR |
Subject in Portuguese | Hipertensão essencial | pt_BR |
Subject in Portuguese | Risco ambiental | pt_BR |
Subject in Portuguese | Genética | pt_BR |
Title | Combined analysis of genetic and environmental factors on essential hypertension in a brazilian rural population in the Amazon region | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/s0066-782x2007000400014 | |
Abstract | Objective: In the present study, we evaluated the contribution of six genetic polymorphisms of the Renin-AngiotensisAldosterone system (RAAS) and clinical risk factors in the development of essential hypertension in a Brazilian rural population in the Amazon region. Methods: Eighty-two hypertensive patients and seventy-eight normotensive individuals were evaluated. Genotyping for renin (REN G1051A), angiotensinogen (AGT) M235T, insertion/deletion of angiotensin-converting enzyme (ACE I/D), angiotensin II type 1 receptor (AGTR1) A1166C and aldosterone synthase (CYP11B2) C344T polymorphisms were performed using polymerase chain reaction, with further restriction analysis when required. The influence of genetic polymorphisms and clinical risk factors on blood pressure variation was assessed by stepwise linear regression. Results: We report the co-occurrence of clinical risk factors and angiotensin-converting enzyme (ACE) gene polymorphism in a Brazilian rural population in the Amazon region. Our results indicate that increase of systolic blood pressure (SBP) is favored by ACE I/D- D allele and advanced age, while alcohol consumption and aging are associated with high diastolic blood pressure (DBP). Conclusion: These findings suggest that in the Santa Isabel do Rio Negro population, the residents that carry ACE-D allele or have an alcohol consumption habit present higher values of SBP and DBP, respectively, with the passing of years. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | UNIGRANRIO. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Polymorphisms | pt_BR |
Subject | Essential hypertension | pt_BR |
Subject | Environmental risk | pt_BR |
Subject | Genetic | pt_BR |
e-ISSN | 1678-4170 | |