| Author | Cunha, Ildenize Barbosa da Silva | |
| Author | Salomão, Kelly | |
| Author | Shimizu, Mario | |
| Author | Bankova, Vassya S. | |
| Author | Custódio, Angela Ramalho | |
| Author | Castro, Solange Lisboa de | |
| Author | Marcucci, Maria Cristina | |
| Access date | 2020-05-20T14:45:58Z | |
| Available date | 2020-05-20T14:45:58Z | |
| Document date | 2004 | |
| Citation | CUNHA, Ildenize Barbosa da Silva et al. Antitrypanosomal activity of Brazilian Propolis from Apis Mellifera. Chem. Pharm. Bull., v. 52, n. 5, p. 602-604, 2004. | pt_BR |
| ISSN | 0009-2363 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/41321 | |
| Language | eng | pt_BR |
| Publisher | Pharmaceutical Society of Japan | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Própolis brasileiro | pt_BR |
| Subject in Portuguese | Composição química | pt_BR |
| Subject in Portuguese | HPLC | pt_BR |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Procedimento de extração | pt_BR |
| Title | Antitrypanosomal activity of Brazilian Propolis from apis mellifera | pt_BR |
| Type | Article | |
| DOI | 10.1248/cpb.52.602 | |
| Abstract | Extracts from different samples of Brazilian propolis were obtained by Soxhlet extraction or maceration at
room temperature using ethanol, water, and accombination of both solvents. Analysis of their composition using
HPLC revealed that no major differences were seen when a propolis sample was subject to different extraction
methods. The activity of the 15 extracts was assayed against bloodstream trypomastigotes of Trypanosoma cruzi,
the etiologic agent of Chagas’ disease. Multivariate analysis was applied to evaluate the efficiency of the different
extracts and the trypanocidal activity. The extracts could be divided into two groups. In the first, in which, extracts
were obtained by reflux in Soxhlet using 100% ethanol, there was a lower content of bioactive compounds
and consequently lower trypanocidal activity. Extract 136-Et100 stands out in this group, since it had the highest
levels of bioactive compounds together with highest activity against the parasite when compared with all other
extracts. The second group comprises extracts with intermediate levels of bioactive compounds and higher activity
against T. cruzi. | pt_BR |
| Affilliation | Universidade São Francisco. Faculdade de Ciências Farmacêuticas. Bragança Paulista, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-Estrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade São Francisco. Faculdade de Ciências Farmacêuticas. Bragança Paulista, SP, Brasil. | pt_BR |
| Affilliation | Bulgarian Academy of Scienses. Institute of Organic Chemistry with Centre for Phytochemisty. Sofia, Bulgaria. | pt_BR |
| Affilliation | Natural Labor, Análises e Pesquisas. Campinas, SP, Brasil. | pt_BR |
| Affilliation | Universidade Bandeirante de São Paulo. Núcleo de Pós-Graduação, Pesquisa e Extensão. São Paulo, SP, Brasil. . | pt_BR |
| Subject | Brazilian propolis | pt_BR |
| Subject | Extraction procedure | pt_BR |
| Subject | Chemical composition | pt_BR |
| Subject | HPLC | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| e-ISSN | 1347-5223 | |
