| Author | Vianna, Renata Artimos de Oliveira | |
| Author | Lovero, Kathryn Lynn | |
| Author | Oliveira, Solange Artimos de | |
| Author | Fernandes, Alexandre Ribeiro | |
| Author | Santos, Teresa Cristina Sarmet dos | |
| Author | Lima, Luiz Cláudio Santos de Souza | |
| Author | Carvalho, Fabiana Rabe | |
| Author | Quintans, Maria Dolores Salgado | |
| Author | Bueno, Arnaldo Costa | |
| Author | Torbey, Ana Flávia Malheiros | |
| Author | Souza, Aurea Lucia Alves Azevedo Grippa de | |
| Author | Farias, Armanda de Oliveira Pache de | |
| Author | Camacho, Luiz Antonio Bastos | |
| Author | Riley, Lee Woodland | |
| Author | Cardoso, Claudete Aparecida Araújo | |
| Access date | 2020-06-03T14:23:15Z | |
| Available date | 2020-06-03T14:23:15Z | |
| Document date | 2019 | |
| Citation | VIANNA, Renata A. de Oliveira et al. Children born to mothers with rash during Zika Virus Epidemic in Brazil: first 18 months of life. J. Tropical Pediatrics, v.65, n.6, p.592-602, 2019. | pt_BR |
| ISSN | 0142-6338 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/41499 | |
| Language | eng | pt_BR |
| Publisher | Oxford University Press | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Zika Virus | pt_BR |
| Subject in Portuguese | Microcefalia | pt_BR |
| Title | Children born to mothers with rash during Zika Virus Epidemic in Brazil: first 18 months of life | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1093/tropej/fmz019 | |
| Abstract | Objective: To better understand the clinical spectrum and course of congenital Zika syndrome (CZS) during the first 18 months of life of children whose mothers had rash during pregnancy. Methods: This longitudinal observational study evaluated the clinical progress from birth until 18 months of life of children of mothers who developed rash during or up to 3 months before gestation. Maternal rash occurred from November 2015 to May 2017. The study subjects were divided into three groups: children whose mothers tested positive by RT-qPCR for Zika virus (ZIKV) (Group 1), children whose mothers tested negative by RT-qPCR for ZIKV (Group 2), and children whose mothers did not undergo any testing for ZIKV (Group 3) but tested negative for other congenital infections. Results: Between April 2016 and July 2018, we studied 108 children: 43 in Group 1, 26 in Group 2 and 39 in Group 3. The majority of children were admitted into the study within 6 months of life. CZS was diagnosed in 26 children, equally distributed in Groups 1 and 3. Of 18 children with microcephaly, 6 were in Group 1 (1 postnatal) and 12 were in Group 3 (5 postnatal). Maternal rash frequency was 10 times higher during the first trimester than in the other trimesters (OR: 10.35; CI 95%: 3.52-30.41). CZS was diagnosed during the follow-up period in 14 (54%) cases. Developmental delays and motor abnormalities occurred in all children and persisted up to 18 months. Epilepsy occurred in 18 (69%) of the cases. Conclusions: Infants born of mothers exposed to ZIKV during pregnancy showed progression of developmental, motor and neurologic abnormalities even if they were born asymptomatic. Continued postnatal monitoring of such newborns is necessary to preclude disability-associated complications. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | University of Columbia. Department of Psychiatry. New York, USA. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Epidemiologia e Métodos Quantitativos em Saúde. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University of California. Division of Infectious Diseases and Vaccinology. Berkeley, USA. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil. | pt_BR |
| Subject | Congenital Zika Syndrome | pt_BR |
| Subject | RT-PCR | pt_BR |
| Subject | Zika Virus | pt_BR |
| Subject | Microcephaly | pt_BR |
| DeCS | Zika Virus | pt_BR |
| DeCS | Microcephaly | pt_BR |
| e-ISSN | 1465-3664 | |
