| Author | Rolfes, Verena | |
| Author | Ribeiro, Lucas Secchim | |
| Author | Hawwari, Ibrahim | |
| Author | Böttcher, Lisa | |
| Author | Rosero, Nathalia | |
| Author | Maasewerd, Salie | |
| Author | Santos, Marina Lima Silva | |
| Author | Próchnicki, Tomasz | |
| Author | Silva, Camila Meirelles de Souza | |
| Author | Wanderley, Carlos Wagner de Souza | |
| Author | Rothe, Maximilian | |
| Author | Schmidt, Susanne V. | |
| Author | Stunden, H. James | |
| Author | Bertheloot, Damien | |
| Author | Rivas, Magali Noval | |
| Author | Fontes, Cor Jesus | |
| Author | Carvalho, Luzia Helena | |
| Author | Cunha, Fernando Queiroz | |
| Author | Latz, Eicke | |
| Author | Arditi, Moshe | |
| Author | Franklin, Bernardo Simoes | |
| Access date | 2020-06-03T15:55:26Z | |
| Available date | 2020-06-03T15:55:26Z | |
| Document date | 2020 | |
| Citation | ROLFES, Verena et al. Platelets Fuel the Inflammasome Activation of Innate Immune Cells. Cell Reports, v. 31, n. 6, 107615, 2020 | pt_BR |
| ISSN | 2211-1247 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/41504 | |
| Language | eng | pt_BR |
| Publisher | Elsevier Inc. | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Platelets Fuel the Inflammasome Activation of Innate Immune Cells | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.celrep.2020.107615 | |
| Abstract | The inflammasomes control the bioactivity of pro-inflammatory cytokines of the interleukin (IL)-1 family. The inflammasome assembled by NLRP3 has been predominantly studied in homogeneous cell populations in vitro, neglecting the influence of cellular interactions that occur in vivo. Here, we show that platelets boost the inflammasome capacity of human macrophages and neutrophils and are critical for IL-1 production by monocytes. Platelets license NLRP3 transcription, thereby enhancing ASC oligomerization, caspase-1 activity, and IL-1β secretion. Platelets influence IL-1β production in vivo, and blood platelet counts correlate with plasmatic IL-1β levels in malaria. Furthermore, we reveal an enriched platelet gene signature among the highest-expressed transcripts in IL-1β-driven autoinflammatory diseases. The platelet effect is independent of cell-to-cell contact, platelet-derived lipid mediators, purines, nucleic acids, and a host of platelet cytokines, and it involves the triggering of calcium-sensing receptors on macrophages. Hence, platelets provide an additional layer of regulation of inflammasomes and IL-1-driven inflammation. | pt_BR |
| Affilliation | Institute of Innate Immunity. Medical Faculty. University of Bonn. 53127 Bonn, NRW, Germany | pt_BR |
| Affilliation | Institute of Innate Immunity. Medical Faculty. University of Bonn. 53127 Bonn, NRW, Germany | pt_BR |
| Affilliation | Institute of Innate Immunity. Medical Faculty. University of Bonn. 53127 Bonn, NRW, Germany | pt_BR |
| Affilliation | Institute of Innate Immunity. Medical Faculty. University of Bonn. 53127 Bonn, NRW, Germany | pt_BR |
| Affilliation | Institute of Innate Immunity. Medical Faculty. University of Bonn. 53127 Bonn, NRW, Germany | pt_BR |
| Affilliation | Institute of Innate Immunity. Medical Faculty. University of Bonn. 53127 Bonn, NRW, Germany | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Institute of Innate Immunity. Medical Faculty. University of Bonn. 53127 Bonn, NRW, Germany | pt_BR |
| Affilliation | Institute of Innate Immunity. Medical Faculty. University of Bonn. 53127 Bonn, NRW, Germany | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Centro de Pesquisa em Doenças Inflamatórias. Ribeirão Preto, SP, Brasil | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Centro de Pesquisa em Doenças Inflamatórias. Ribeirão Preto, SP, Brasil | pt_BR |
| Affilliation | Institute of Innate Immunity. Medical Faculty. University of Bonn. 53127 Bonn, NRW, Germany | pt_BR |
| Affilliation | Institute of Innate Immunity. Medical Faculty. University of Bonn. 53127 Bonn, NRW, Germany | pt_BR |
| Affilliation | Institute of Innate Immunity. Medical Faculty. University of Bonn. 53127 Bonn, NRW, Germany | pt_BR |
| Affilliation | Institute of Innate Immunity. Medical Faculty. University of Bonn. 53127 Bonn, NRW, Germany | pt_BR |
| Affilliation | Departments of Pediatrics, Division of Infectious Diseases and Immunology, and Infectious and Immunologic Diseases Research Center (IIDRC. Department of Biomedical Sciences. Cedars-Sinai Medical Center, Los Angeles, CA | pt_BR |
| Affilliation | Universidade Federal de Mato Grosso. Departamento de Clínica Médica. Cuiabá, MT, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Centro de Pesquisa em Doenças Inflamatórias. Ribeirão Preto, SP, Brazil | pt_BR |
| Affilliation | Institute of Innate Immunity. Medical Faculty. University of Bonn. 53127 Bonn, NRW, Germany/Department of Infectious Diseases and Immunology. University of Massachusetts Medical School. Worcester, MA 01655, USA/German Center for Neurodegenerative Diseases. 53127 Bonn, NRW, Germany | pt_BR |
| Affilliation | Departments of Pediatrics, Division of Infectious Diseases and Immunology, and Infectious and Immunologic Diseases Research Center (IIDRC. Department of Biomedical Sciences. Cedars-Sinai Medical Center, Los Angeles, CA | pt_BR |
| Affilliation | Institute of Innate Immunity. Medical Faculty. University of Bonn. 53127 Bonn, NRW, Germany | pt_BR |
| Subject | inflammasomes | pt_BR |
| Subject | interleukin-1 | pt_BR |
| Subject | platelets | pt_BR |
| Subject | auto-inflammatory diseases | pt_BR |
| Subject | malaria | pt_BR |
| Subject | NLRP3 | pt_BR |
| Subject | ASC | pt_BR |
| Subject | Caspase-1 | pt_BR |
| Subject | Cell Death | pt_BR |
| Subject | Pyroptosis | pt_BR |
| Embargo date | 2035-01-01 | |
