| Author | Vinhaes, Caian L. | |
| Author | Arriaga Gutiérrez, María Belen | |
| Author | Almeida, Breno L. de | |
| Author | Oliveira, João V. | |
| Author | Santos, Cleiton S. | |
| Author | Calcagno, Juan I. | |
| Author | Carvalho, Tereza X. | |
| Author | Giovanetti, Marta | |
| Author | Alcantara, Luiz Carlos Junior | |
| Author | Siqueira, Isadora Cristina de | |
| Author | Andrade, Bruno de Bezerril | |
| Access date | 2020-06-10T13:39:46Z | |
| Available date | 2020-06-10T13:39:46Z | |
| Document date | 2020 | |
| Citation | VINHAES, Caian L. et al. wNewborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance. The Journal of Infectious Disease, p. 1-11, 2020. | pt_BR |
| ISSN | 0022-1899 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/41601 | |
| Sponsorship | Fundação Oswaldo Cruz, Conselho
Nacional de Desenvolvimento Científico e Tecnológico
([CNPq] award numbers 443875/2018-9 and 425380/2016)
and Fundação de Amparo à Pesquisa do Estado da Bahia
([FAPESB] award number PPSUS/BA-FAPESB003/2017/
SESAB/CNPq/MS 5125/2017). L. C. J. A., M. G., and
B. L. d. A. were supported by CNPq/Ministério da Ciência,
Tecnologia e Inovação (MCTI), Departamento de Ciência
e Tecnologia (DECIT)/Secretaria de Ciência, Tecnologia
e Insumos Estratégicos (SCTIE)/Ministério da Saúde
(440685/2016–8), and Coordenação de Aperfeiçoamento de
Pessoal de Nível Superior (CAPES) (88887.130716/2016-00).
L. C. J. A. and I. C. d. S. were supported by the European
Union’s Horizon 2020 Programme through ZIKAlliance
(Grant No. PRES-005- FEX-17-4-2-33). The work from
B. B. A. was supported by the National Institutes of Health
(U01AI115940) and by CNPq (senior fellowship). M. B.
A. received a fellowship from the FAPESB. C. L. V. is a scientific
initiation fellow from CNPq. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Oxford University Press | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Inflamação | pt_BR |
| Subject in Portuguese | Microcefalia | pt_BR |
| Subject in Portuguese | Recém-nascidos | pt_BR |
| Subject in Portuguese | Vírus zika | pt_BR |
| Title | Newborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance | pt_BR |
| Type | Article | |
| DOI | 10.1093/infdis/jiaa197 | |
| Abstract | Zika Virus (ZIKV) is an emergent flavivirus initially considered a benign and self-limited exanthematic illness. In 2015, a new epidemic emerged in northeastern of Brazil with increased incidence of a previously rare clinical outcome, microcephaly, in newborns from mothers who were infected during pregnancy. Little is known about the immunopathogenesis of ZIKV-associated microcephaly. Understanding the inflammatory profile and degree of inflammation of persons affected with such condition is an important step towards development of innovative therapeutic strategies. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Secretaria de Saúde do Estado da Bahia. Maternidade de Referência Prof. José Maria de Magalhães Netto. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Secretaria de Saúde do Estado da Bahia. Maternidade de Referência Prof. José Maria de Magalhães Netto. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Universidade Salvador. Laureate Universities. Salvador, BA, Brasil / IUniversity of Cape Town. Institute of Infectious Disease and Molecular Medicine. Centre for Infectious Disease Research in Africa. Cape Town, South Africa / Escola Bahiana de Medicina e Saúde Pública, Salvador, BA, Brasil. | pt_BR |
| Subject | Inflammation | pt_BR |
| Subject | Microcephaly | pt_BR |
| Subject | Newborns | pt_BR |
| Subject | Zika virus | pt_BR |
