Author | Dantas, Lindaiane Bezerra Rodrigues | |
Author | Silva, Ana Letícia Moreira | |
Author | Silva Júnior, Cícero Pedro da | |
Author | Alcântara, Isabel Sousa | |
Author | Oliveira, Maria Rayane Correia de | |
Author | Martins, Anita Oliveira Brito Pereira Bezerra | |
Author | Ribeiro Filho, Jaime | |
Author | Coutinho, Henrique Douglas Melo | |
Author | Passos, Fabíolla Rocha Santos | |
Author | Quintans Junior, Lucindo José | |
Author | Menezes, Irwin Rose Alencar de | |
Author | Pezzani, Raffaele | |
Author | Vitalini, Sara | |
Access date | 2020-06-22T12:16:31Z | |
Available date | 2020-06-22T12:16:31Z | |
Document date | 2020 | |
Citation | DANTAS, Lindaiane Bezerra Rodrigues et al. Nootkatone Inhibits Acute and Chronic Inflammatory Responses in Mice. Molecules, v. 25, p. 2581, 2020. | pt_BR |
ISSN | 1420-3049 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/41792 | |
Sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brasil
(CAPES), Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico (FUNCAP) and Conselho
Nacional de Desenvolvimento Científico e Tecnológico (CNPq)–finance code 304291/2017-0 and Financiadora de
Estudos e Projetos-Brasil (FINEP). | pt_BR |
Language | eng | pt_BR |
Publisher | MDPI | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Nootkatone | pt_BR |
Subject in Portuguese | Anti-inflamatório | pt_BR |
Subject in Portuguese | Inflamação aguda | pt_BR |
Subject in Portuguese | Granuloma | pt_BR |
Title | Nootkatone Inhibits Acute and Chronic Inflammatory Responses in Mice | pt_BR |
Type | Article | pt_BR |
DOI | 10.3390/molecules25092181 | |
Abstract | Nootkatone (NTK) is a sesquiterpenoid found in essential oils of many species of Citrus (Rutaceae). Considering previous reports demonstrating that NTK inhibited inflammatory signaling pathways, this study aimed to investigate the effects of this compound in mice models of acute and chronic inflammation. Murine models of paw edema induced by carrageenan, dextran, histamine, and arachidonic acid, as well as carrageenan-induced peritonitis and pleurisy, were used to evaluate the effects of NTK on acute inflammation. A murine model of granuloma induced by cotton pellets was used to access the impact of NTK treatment on chronic inflammation. In the acute inflammation models, NTK demonstrated antiedematogenic effects and inhibited leukocyte recruitment, which was associated with decreased vascular permeability, inhibition of myeloperoxidase (MPO), interleukin (IL)1-β, and tumor necrosis factor (TNF)-α production. In silico analysis suggest that NTZ anti-inflammatory effects may also occur due to inhibition of cyclooxygenase (COX)-2 activity and antagonism of the histamine receptor type 1 (H1). These mechanisms might have contributed to the reduction of granuloma weight and protein concentration in the homogenates, observed in the chronic inflammation model. In conclusion, NTK exerted anti-inflammatory effects that are associated with inhibition of IL1-β and TNF-α production, possibly due to inhibition of COX-2 activity and antagonism of the H1 receptor. However, further studies are required to characterize the effects of this compound on chronic inflammation. | pt_BR |
Affilliation | Centro Universitário Dr. Leão Sampaio-UNILEÃO. Departamento de Saúde. Juazeiro do Norte, CE, Brasil. | pt_BR |
Affilliation | Centro Universitário Dr. Leão Sampaio-UNILEÃO. Departamento de Saúde. Juazeiro do Norte, CE, Brasil. | pt_BR |
Affilliation | Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brasil. | pt_BR |
Affilliation | Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brasil. | pt_BR |
Affilliation | Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brasil. | pt_BR |
Affilliation | Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Regional University of Cariri. Microbiology and Biology Molecular Laboratory. Department of Chemical Biology. Crato, CE, Brasil. | pt_BR |
Affilliation | Federal University of Sergipe. Graduate Program in Health Sciences. Aracaju, SE, Brasil. | pt_BR |
Affilliation | Federal University of Sergipe. Graduate Program in Health Sciences. Aracaju, SE, Brasil. | pt_BR |
Affilliation | Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brasil. | pt_BR |
Affilliation | University of Padova. O.U. Endocrinology, Department of Medicine. Padova, Italy / Associazione Italiana per la Ricerca Oncologica di Base. Padova, Italy. | pt_BR |
Affilliation | Milan State University. Department of Agricultural and Environmental Sciences. Milan, Italy. | pt_BR |
Subject | Nootkatone | pt_BR |
Subject | Anti-inflammatory | pt_BR |
Subject | Acute inflammation | pt_BR |
Subject | Granuloma | pt_BR |