| Author | Longley, Rhea J. | |
| Author | White, Michael T. | |
| Author | Takashima, Eizo | |
| Author | Brewster, Jessica | |
| Author | Morita, Masayuki | |
| Author | Harbers, Matthias | |
| Author | Obadia, Thomas | |
| Author | Robinson, Leanne J. | |
| Author | Matsuura, Fumie | |
| Author | Liu, Zoe S. J. | |
| Author | Li-Wai-Suen, Connie S. N. | |
| Author | Tham, Wai-Hong | |
| Author | Healer, Julie | |
| Author | Huon, Christele | |
| Author | Chitnis, Chetan E. | |
| Author | Nguitragool, Wang | |
| Author | Monteiro, Wuelton | |
| Author | Proietti, Carla | |
| Author | Doolan, Denise L. | |
| Author | Siqueira, Andre M. | |
| Author | Ding, Xavier C. | |
| Author | Gonzalez, Iveth J. | |
| Author | Kazura, James | |
| Author | Lacerda, Marcus | |
| Author | Sattabongkot, Jetsumon | |
| Author | Tsuboi, Takafumi | |
| Author | Mueller, Ivo | |
| Access date | 2020-06-25T21:00:36Z | |
| Available date | 2020-06-25T21:00:36Z | |
| Document date | 2020 | |
| Citation | LONGLEY, Rhea J. et al. Development and validation of serological markers for detecting recent Plasmodium vivax infection. Nature Medicine, v. 26, n. 5, p. 741-749, 2020. | pt_BR |
| ISSN | 1078-8956 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/41895 | |
| Language | eng | pt_BR |
| Publisher | Nature Research | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Development and validation of serological markers for detecting recent Plasmodium vivax infection | pt_BR |
| Type | Article | |
| DOI | 10.1038/s41591-020-0841-4 | |
| Abstract | A major gap in the Plasmodium vivax elimination toolkit is the identification of individuals carrying clinically silent and undetectable liver-stage parasites, called hypnozoites. This study developed a panel of serological exposure markers capable of classifying individuals with recent P. vivax infections who have a high likelihood of harboring hypnozoites. We measured IgG antibody responses to 342 P. vivax proteins in longitudinal clinical cohorts conducted in Thailand and Brazil and identified candidate serological markers of exposure. Candidate markers were validated using samples from year-long observational cohorts conducted in Thailand, Brazil and the Solomon Islands and antibody responses to eight P. vivax proteins classified P. vivax infections in the previous 9 months with 80% sensitivity and specificity. Mathematical models demonstrate that a serological testing and treatment strategy could reduce P. vivax prevalence by 59-69%. These eight antibody responses can serve as a biomarker, identifying individuals who should be targeted with anti-hypnozoite therapy. | pt_BR |
| Affilliation | Walter and Eliza Hall Institute of Medical Research. Population Health and Immunity Division. Melbourne, Victoria, Australia / University of Melbourne. Department of Medical Biology. Melbourne, Victoria, Australia / Mahidol University. Faculty of Tropical Medicine. Mahidol Vivax Research Unit. Bangkok, Thailand. | pt_BR |
| Affilliation | Institut Pasteur. Département Parasites et Insectes Vecteurs. Unité Malaria: Parasites et Hôtes. Paris, France. | pt_BR |
| Affilliation | Ehime University. Proteo-Science Center. Division of Malaria Research. Matsuyama, Japan. | pt_BR |
| Affilliation | Walter and Eliza Hall Institute of Medical Research. Population Health and Immunity Division. Melbourne, Victoria, Australia. | pt_BR |
| Affilliation | Ehime University. Proteo-Science Center. Division of Malaria Research. Matsuyama, Japan. | pt_BR |
| Affilliation | CellFree Sciences Co. Ltd. Yokohama, Japan / RIKEN Center for Integrated Medical Sciences. Yokohama, Japan. | pt_BR |
| Affilliation | Institut Pasteur. Département Parasites et Insectes Vecteurs. Unité Malaria: Parasites et Hôtes. Paris, France / Institut Pasteur. Département Biologie Computationnelle. Hub de Bioinformatique et Biostatistique. Paris, France. | pt_BR |
| Affilliation | Walter and Eliza Hall Institute of Medical Research. Population Health and Immunity Division. Melbourne, Victoria, Australia / University of Melbourne. Department of Medical Biology. Melbourne, Victoria, Australia / Burnet Institute. Melbourne, Victoria, Australia. | pt_BR |
| Affilliation | CellFree Sciences Co. Ltd. Yokohama, Japan. | pt_BR |
| Affilliation | Walter and Eliza Hall Institute of Medical Research. Population Health and Immunity Division. Melbourne, Victoria, Australia / University of Melbourne. Department of Medical Biology. Melbourne, Victoria, Australia. | pt_BR |
| Affilliation | Walter and Eliza Hall Institute of Medical Research. Population Health and Immunity Division. Melbourne, Victoria, Australia / University of Melbourne. Department of Medical Biology. Melbourne, Victoria, Australia. | pt_BR |
| Affilliation | University of Melbourne. Department of Medical Biology. Melbourne, Victoria, Australia / Walter and Eliza Hall Institute of Medical Research. Infection and Immunity Division. Melbourne, Victoria, Australia. | pt_BR |
| Affilliation | University of Melbourne. Department of Medical Biology. Melbourne, Victoria, Australia / Walter and Eliza Hall Institute of Medical Research. Infection and Immunity Division. Melbourne, Victoria, Australia. | pt_BR |
| Affilliation | Institut Pasteur. Department of Parasites & Insect Vectors. Malaria Parasite Biology and Vaccines. Paris, France. | pt_BR |
| Affilliation | Institut Pasteur. Department of Parasites & Insect Vectors. Malaria Parasite Biology and Vaccines. Paris, France. | pt_BR |
| Affilliation | Mahidol University. Faculty of Tropical Medicine. Department of Molecular Tropical Medicine and Genetics. Bangkok, Thailand. | pt_BR |
| Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Manaus, AM, Brasil. | pt_BR |
| Affilliation | James Cook University. Australian Institute of Tropical Health and Medicine. Centre for Molecular Therapeutics. Cairns, Queensland, Australia / QIMR Berghofer Medical Research Institute. Brisbane, Queensland, Australia. | pt_BR |
| Affilliation | James Cook University. Australian Institute of Tropical Health and Medicine. Centre for Molecular Therapeutics. Cairns, Queensland, Australia / QIMR Berghofer Medical Research Institute. Brisbane, Queensland, Australia. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Foundation for Innovative New Diagnostics. Geneva, Switzerland. | pt_BR |
| Affilliation | Foundation for Innovative New Diagnostics. Geneva, Switzerland. | pt_BR |
| Affilliation | Case Western Reserve University. Center for Global Health and Diseases. Cleveland, OH, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Leônidas & Maria Deane. Manaus, AM, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil. | pt_BR |
| Affilliation | Mahidol University. Faculty of Tropical Medicine. Mahidol Vivax Research Unit. Bangkok, Thailand. | pt_BR |
| Affilliation | Ehime University. Proteo-Science Center. Division of Malaria Research. Matsuyama, Japan. | pt_BR |
| Affilliation | Walter and Eliza Hall Institute of Medical Research. Population Health and Immunity Division. Melbourne, Victoria, Australia / University of Melbourne. Department of Medical Biology. Melbourne, Victoria, Australia / Institut Pasteur. Département Parasites et Insectes Vecteurs. Unité Malaria: Parasites et Hôtes. Paris, France. | pt_BR |
| Subject | Developing world | pt_BR |
| Subject | Epidemiology | pt_BR |
| Subject | Malaria | pt_BR |
| Subject | Parasite host response | pt_BR |
| Subject | Translational research | pt_BR |
| Embargo date | 2030-12-31 | |
