| Author | Rodrigues Junior, Luiz Fernando | |
| Author | Mendes, Fernanda de Souza Nogueira Sardinha | |
| Author | Pinto, Vivian Liane Mattos | |
| Author | Silva, Paula Simplicio | |
| Author | Silva, Gilberto Marcelo Sperandio da | |
| Author | Pinheiro, Roberta Olmo | |
| Author | Sousa, Andréa Silvestre | |
| Author | Mediano, Mauro Felippe Felix | |
| Access date | 2020-06-25T21:18:29Z | |
| Available date | 2020-06-25T21:18:29Z | |
| Document date | 2020 | |
| Citation | RODRIGUES JUNIOR, Luiz Fernando et al. A cardiac rehabilitation exercise program potentially inhibits progressive inflammation in patients with severe Chagas cardiomyopathy: A pilot single-arm clinical trial. Journal of research in medical sciences, v. 25, n. 18, p. 1-4, 2020. | pt_BR |
| ISSN | 1735-1995 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/41896 | |
| Language | eng | pt_BR |
| Publisher | Medknow Publications | pt_BR |
| Rights | open access | pt_BR |
| Title | A cardiac rehabilitation exercise program potentially inhibits progressive inflammation in patients with severe Chagas cardiomyopathy: A pilot single-arm clinical trial | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.4103/jrms.JRMS_175_18 | |
| Abstract | Background: Cardiac rehabilitation exerts anti-inflammatory effect on several cardiovascular diseases; however, these effects were not described for Chagas cardiomyopathy, which is associated with pro-inflammatory imbalance.
Materials and methods: Ten patients with severe Chagas cardiomyopathy performed 8 months of exercise training in a cardiac rehabilitation program. Interleukin-1 beta (IL-1β), IL-8, IL-10, interferon gamma (IF-γ), tumor necrosis factor alpha (TNF-α), and monocyte chemoattractant protein-1 (MCP-1) serum levels were measured using enzyme-linked immunosorbent assay at baseline, 4, and 8 months. The influence of exercise on cytokine levels was evaluated using the one-way analysis of variance for repeated measurements, with Bonferroni posttest for multiple comparisons.
Results: Levels of pro-inflammatory (TNF-α, IL-1β, IL-8, IF-γ, and (MCP-1) and anti-inflammatory (IL-10) cytokines did not vary significantly during the observation period.
Conclusion: Exercise may benefit patients with severe Chagas cardiomyopathy by curbing the production of pro-inflammatory cytokines in this disease characterized by a continuous state of inflammation. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Cardiologia. Serviço de Fisioterapia. Divisão de Apoio ao Cuidado. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Cardiac rehabilitation | pt_BR |
| Subject | Chagas cardiomyopathy | pt_BR |
| Subject | Cytokines | pt_BR |
| Subject | Heart failure | pt_BR |
