| Author | Biembengut, Ísis Venturi | pt_BR |
| Author | Souza, Tatiana de Arruda Campos Brasil de | pt_BR |
| Access date | 2020-06-30T15:12:02Z | |
| Available date | 2020-06-30T15:12:02Z | |
| Document date | 2020 | |
| Citation | BIEMBENGUT, Ísis Venturi; SOUZA, Tatiana de Arruda Campos Brasil de. Coagulation modifiers targeting SARS-CoV-2 main protease Mpro for COVID-19 treatment: an in silico approach. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 19, p. 1-4, 2020. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/42002 | |
| Language | eng | pt_BR |
| Publisher | Fiocruz/IOC | pt_BR |
| Previous version | https://www.arca.fiocruz.br/handle/icict/40946 | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Coronavírus | pt_BR |
| Subject in Portuguese | COVID-19 | pt_BR |
| Subject in Portuguese | SARS-CoV-2 | pt_BR |
| Title | Coagulation modifiers targeting SARS-CoV-2 main protease Mpro for COVID-19 treatment: an in silico approach | en |
| Type | Article | pt_BR |
| DOI | 10.1590/0074-02760200179 | pt_BR |
| Abstract | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection depends on viral polyprotein processing, catalysed by the main proteinase (Mpro). The solution of the SARS-CoV-2 Mpro structure allowed the investigation of potential inhibitors. This work aims to provide first evidences of the applicability of commercially approved drugs to treat coronavirus disease-19 (COVID-19). We screened 4,334 compounds to found potential inhibitors of SARS-CoV-2 replication using an in silico approach. Our results evidenced the potential use of coagulation modifiers in COVID-19 treatment due to the structural similarity of SARS-CoV-2 Mpro and human coagulation factors thrombin and Factor Xa. Further in vitro and in vivo analysis are needed to corroborate these results. | en |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
| Subject | Structure | en |
| Subject | Ligand binding | en |
| Subject | In silico approach | en |
| Subject | COVID-19 | en |
| Subject | SARS-CoV-2 Mpro | en |
| DeCS | SARS-CoV-2 | pt_BR |
| DeCS | COVID-19 | pt_BR |
| DeCS | Infecções por Coronavirus | pt_BR |
| DeCS | Proteínas de Transporte | pt_BR |
| DeCS | Simulação por Computador | pt_BR |
| DeCS | Estrutura Molecular | pt_BR |
