| Author | Fonseca, Ana Carolina Proença da | |
| Author | Abreu, Gabriella de Medeiros | |
| Author | Zembrzuski, Veronica Marques | |
| Author | Campos Junior, Mario | |
| Author | Carneiro, João Regis Ivar | |
| Author | Nogueira Neto, José Firmino | |
| Author | Cabello, Giselda Maria Kalil | |
| Author | Cabello, Pedro Hernán | |
| Access date | 2020-07-02T19:12:11Z | |
| Available date | 2020-07-02T19:12:11Z | |
| Document date | 2019 | |
| Citation | FONSECA, Ana Carolina Proença da et al. The association of the fat mass and obesity-associated gene (FTO) rs9939609 polymorphism and the severe obesity in a Brazilian population. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, v. 12, p. 667-684, 2019. | pt_BR |
| ISSN | 1178-7007 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/42048 | |
| Language | eng | pt_BR |
| Publisher | Dove Medical Press | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Caminho leptina-melanocortina | pt_BR |
| Subject in Portuguese | Obesidade | pt_BR |
| Subject in Portuguese | Polimorfismos | pt_BR |
| Subject in Portuguese | Hipotálamo | pt_BR |
| Title | The Association of the Fat Mass and Obesity-Associated Gene (FTO) rs9939609 Polymorphism and the Severe Obesity in a Brazilian Population | pt_BR |
| Type | Article | |
| Abstract | Obesity occurs due to the interaction between the genetic background and
environmental factors, including an increased food intake and a sedentary lifestyle.
Nowadays, it is clear that there is a specific circuit, called leptin-melanocortin pathway,
which stimulates and suppresses food intake and energy expenditure. Therefore, the aim of
this study was to evaluate the influence of genetic variants related to appetite regulation and
energy expenditure on severe obesity susceptibility and metabolic phenotypes in a Brazilian
cohort. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Departamento e Laboratório de Patologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil / Universidade Grande Rio. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Leptin-melanocortin pathway | pt_BR |
| Subject | FTO | pt_BR |
| Subject | Obesity | pt_BR |
| Subject | Polymorphisms | pt_BR |
| Subject | Hypothalamus | pt_BR |
| e-ISSN | 10.2147/DMSO.S199542. eCollection 2019 | |
