| Author | Barretto, Junaura R | |
| Author | Boa-Sorte, Ney | |
| Author | Vinhaes, Caian L | |
| Author | Santos, Hayna Malta | |
| Author | Ramos, Camila F | |
| Author | Nascimento, Monica A. S. Torres | |
| Author | Borges, Valeria de Matod | |
| Author | Andrade, Bruno de Bezerril | |
| Access date | 2020-07-14T12:18:04Z | |
| Available date | 2020-07-14T12:18:04Z | |
| Document date | 2020 | |
| Citation | BARRETTO, Junaura R. et al. Heightened Plasma Levels of Transforming Growth Factor Beta (TGF-β) and Increased Degree of Systemic Biochemical Perturbation Characterizes Hepatic Steatosis in Overweight Pediatric Patients: A Cross-Sectional Study. Nutrients, v. 12, p. 1650, 2020. | pt_BR |
| ISSN | 2072-6643 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/42241 | |
| Sponsorship | Research Program of the Institute Gonçalo Moniz, Fundação
Oswaldo Cruz, Brazil. Valéria M. Borges and Bruno B. Andrade are senior scientist fellows from the Conselho
Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Ney Boa-Sorte received a fellowship from
Fundação Nacional de Desenvolvimento do Ensino Superior Particular (FUNADESP). Caian L. Vinhaes and
Hayna Malta-Santos received a fellowship from the CNPq. Jéssica Rebouças-Silva received a fellowship from the
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (finance code 001). | pt_BR |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Doença hepática gordurosa não alcoólica | pt_BR |
| Subject in Portuguese | Obesidade pediátrica | pt_BR |
| Subject in Portuguese | Fator de crescimento transformador beta | pt_BR |
| Subject in Portuguese | Transaminases | pt_BR |
| Subject in Portuguese | Estudos transversais | pt_BR |
| Title | Heightened Plasma Levels of Transforming Growth Factor Beta (TGF-β) and Increased Degree of Systemic Biochemical Perturbation Characterizes Hepatic Steatosis in Overweight Pediatric Patients: A Cross-Sectional Study | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.3390/nu12061650 | |
| Abstract | Nonalcoholic Fatty Liver Disease (NAFLD) is a common cause of chronic liver disease in childhood and strongly associated with obesity. Routine biochemical non-invasive tests remain with low accuracy for diagnosis of NAFLD. We performed a cross-sectional study to examine potential associations between anthropometric and biochemical parameters, specially TGF-β, a prognosis marker for hepatic steatosis (HS). Between May and October 2019, seventy-two overweight adolescents were enrolled, of which 36 had hepatic steatosis. Hepatic, lipidic and glycemic profiles, and levels of vitamin D, ferritin and TGF-β were analyzed. Hierarchical cluster and a discriminant model using canonical correlations were employed to depict the overall expression profile of biochemical markers and the biochemical degree of perturbation. Median values of alanine aminotransferase (ALT), gamma glutamyl transpeptidase (GGT), and TGF-β were higher in the adolescents with HS. Values of body mass index (BMI)/age and ALT, but not of TGF-β, were gradually increased proportionally to augmentation of steatosis severity. In a multivariate analysis, TGF-β plasma concentrations were associated with occurrence of hepatic steatosis independent of other covariates. Discriminant analysis confirmed that TGF-β concentrations can identify HS cases. Our data reveal that HS patients exhibit a distinct biosignature of biochemical parameters and imply TGF-β as an important biomarker to evaluate risk of steatosis development. | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Fima Lifshitz Metabolic Unit. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Fima Lifshitz Metabolic Unit. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Universidade Salvador. Laureate Universities. Curso de Medicina. Salvador, BA, Brasil. | pt_BR |
| Subject | Non-alcoholic fatty liver disease | pt_BR |
| Subject | Pediatric obesity | pt_BR |
| Subject | Transforming growth factor beta | pt_BR |
| Subject | Systemic biochemical perturbation | pt_BR |
| Subject | Transaminases | pt_BR |
| Subject | Cross-sectional studies | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
