| Author | Nazarkovsky, Michael | |
| Author | Mello, Heber L. de | |
| Author | Bisaggio, Rodrigo C. | |
| Author | Alves, Luiz A. | |
| Author | Zaitsev, Volodymyr | |
| Access date | 2020-07-17T18:52:19Z | |
| Available date | 2020-07-17T18:52:19Z | |
| Document date | 2020 | |
| Citation | NAZARKOVSKY, Michael et al. Hybrid suspension of nanodiamonds-nanosilica/titania in cytotoxicity tests on cancer cell lines. Inorganic Chemistry Communications, v. 111, p. 1-4, 2020. | pt_BR |
| ISSN | 1387-7003 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/42294 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Nanosilica/titania | pt_BR |
| Subject in Portuguese | Nanodiamonds | pt_BR |
| Subject in Portuguese | Citotoxicidade | pt_BR |
| Subject in Portuguese | Câncer | pt_BR |
| Subject in Portuguese | Sarcoma | pt_BR |
| Title | Hybrid suspension of nanodiamonds-nanosilica/titania in cytotoxicity tests on cancer cell lines | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.inoche.2019.107673 | |
| Abstract | The present communication reports the results of application of stable hybrid solid dispersed phase-based
(nanodiamonds-nanosilica/titania) suspensions in cytotoxicity tests, using two different cell lines – the mouse
sarcoma (J774.G8) and the ovarian carcinoma (OVCAR 8). It is also demonstrated that binary (1 wt% of nanodiamonds and 5 wt% of nanosilica/titania) suspension is more stable than individually prepared (nanodiamonds alone) in normal saline solution (0.9 wt% NaCl). With the help of scanning electron microscopy the
structure and the morphology of hybrid aggregate particles in dried suspensions (xerogels) were examined. In
normal saline solution the subject suspensions do not experience the sedimentation by dilution within 24 h after
addition of identical dispersion medium, while the negative zeta-potential (−28.8 mV) decreases to zero (4-
times dilution) and the solid phase is characterized by aggregates size at ≤160 nm from the DLS measurements.
The tests of biocompatibility (cytotoxicity) did not demonstrate any statistically significant toxicity at the suspension in the concentrations range of 0.01–0.155% (in respect to nanodiamonds in the suspensions diluted by
cell culture, wt./vol) of the suspensions. | pt_BR |
| Affilliation | Pontifícia Universidade Católica. Departamento de Química. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil / Instituto Federal do Rio de Janeiro. Departamento de Biotecnologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil / Instituto Federal do Rio de Janeiro. Departamento de Biotecnologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Pontifícia Universidade Católica. Departamento de Química. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Nanodiamonds | pt_BR |
| Subject | Nanodiamonds-nanosilica/titania | pt_BR |
| Subject | Cytotoxicity | pt_BR |
| Subject | Cancer | pt_BR |
| Subject | Sarcoma | pt_BR |
| Embargo date | 2022-01-01 | |
