Author | Salla, L. C. | |
Author | Rodrigues, P. T. | |
Author | Corder, R. M. | |
Author | Johansen, I. C. | |
Author | Ladeia_Andrade, S. | |
Author | Ferreira, M. U. | |
Access date | 2020-07-20T18:53:45Z | |
Available date | 2020-07-20T18:53:45Z | |
Document date | 2020 | |
Citation | SALLA, L. C. et al. Molecular evidence of sustained urban malaria transmission in Amazonian Brazil, 2014–2015. Ecology and Infection, v.48, e47, p. 1-8, 2020. | pt_BR |
ISSN | 0950-2688 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/42306 | |
Language | eng | pt_BR |
Publisher | Cambridge University Press | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Amazônia | pt_BR |
Subject in Portuguese | Epidemiologia molecular | pt_BR |
Subject in Portuguese | Estrutura populacional | pt_BR |
Subject in Portuguese | Área urbana | pt_BR |
Title | Molecular evidence of sustained urban malaria transmission in Amazonian Brazil, 2014–2015 | pt_BR |
Type | Article | pt_BR |
DOI | 10.1017/S0950268820000515 | |
Abstract | The relative contribution of imported vs. locally acquired infections to urban malaria burden remains largely unexplored in Latin America, the most urbanised region in the developing world. Here we use a simple molecular epidemiology framework to examine the transmission dynamics of Plasmodium vivax in Mâncio Lima, the Amazonian municipality with the highest malaria incidence rate in Brazil. We prospectively genotyped 177 P. vivax infections diagnosed in urban residents between June 2014 and July 2015 and showed that local parasites are structured into several lineages of closely related microsatellite haplotypes, with the largest genetic cluster comprising 32% of all infections. These findings are very unlikely under the hypothesis of multiple independent imports of parasite strains from the rural surroundings. Instead, the presence of an endemic near-clonal parasite lineage circulating over 13 consecutive months is consistent with a local P. vivax transmission chain in the town, with major implications for malaria elimination efforts in this and similar urban environments across the Amazon. | pt_BR |
Affilliation | Universidade de São Paulo. Departamento de Parasitologia. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Departamento de Parasitologia. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Departamento de Parasitologia. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Departamento de Parasitologia. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Departamento de Parasitologia. São Paulo, SP, Brasil. | pt_BR |
Subject | Amazon | pt_BR |
Subject | Malaria | pt_BR |
Subject | Molecular epidemiology | pt_BR |
Subject | Urban | pt_BR |
e-ISSN | 1469-4409 | |